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Study of muscle and nerve weakness in neurological and neurosurgical ICU patients on prolonged ventilator support using nerve and ultrasound tests

Critical illness neuropathy and myopathy in neuro-intensive care unit patients - A prospective observational study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/05/110555
Enrollment
168
Registered
2026-05-18
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G00-G99- Diseases of the nervous system Health Condition 2: S069- Unspecified intracranial injury Health Condition 3: C729- Malignant neoplasm of central nervous system, unspecified

Interventions

Intervention1: Nil: Nil

Sponsors

National Institute of Mental Health and Neurosciences NIMHANS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Neurological and neurosurgical patients admitted to the ICU for more than 72 hours and requiring mechanical ventilation

Exclusion criteria

Exclusion criteria: 1. Refusal of consent 2. Pre-existing demyelinating polyneuropathy or neuromuscular disease 3. Diabetes Mellitus for more than 10 years or an admission HbA1c of more than 8% 4. High spinal cord injury and spinal cord tumours. 5. Nerve conduction study suggestive of peripheral neuropathy at baseline

Design outcomes

Primary

MeasureTime frame
To determine the incidence of ICU-acquired weakness in neurological and neurosurgical ICU patients by nerve conduction studies in the upper and lower limbs.Timepoint: Day3, Day7, Day14—

Secondary

MeasureTime frame
To assess muscle strength with the Medical Research Council sum score (MRC-SS) and compare its changes with nerve conduction studies.Timepoint: Day3, Day7, Day14; To assess changes in skeletal muscle architecture (muscle layer thickness, cross-sectional area, echogenicity and presence of fasciculations) and diaphragm function (thickening fraction and excursion of the diaphragm) using ultrasound and to compare their changes with nerve conduction studiesTimepoint: Day3, Day7, Day14; To correlate multimodal findings and clinical outcomes: The clinical outcomes include length of ICU stay, duration of mechanical ventilation, duration of immobilisation, tracheostomy requirement, and functional status at discharge.Timepoint: At discharge from ICU—

Countries

India

Contacts

Public ContactDr Radhakrishnan M

National Institute of Mental Health and Neurosciences(NIMHANS)

mrks1974@gmail.com9632589296

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026