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A Study Comparing Two Blood-Derived Materials with Bone Graft to Improve Healing After Tooth Extraction

Comparative Evaluation of effectiveness of Horizontally Centrifuged Platelet-Rich Fibrin (H-PRF) and PRF in combination with Bovine-Derived Xenograft (FixOss) in Socket preservation: A Randomized Control trial. - NIL

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/110531
Enrollment
30
Registered
2026-05-18
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K089- Disorder of teeth and supporting structures, unspecified

Interventions

Intervention1: Horizontally Centrifuged Platelet-Rich Fibrin (H-PRF) in combination with Bovine-Derived Xenograft (FixOss): Horizontally Centrifuged Platelet-Rich Fibrin (H-PRF) in combination with Bo

Sponsors

Datta Meghe Institute of Higher Education and Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Teeth indicated for extraction due to: Non-restorable caries, Failed endodontic treatment, Root fractures, Periodontal disease with poor prognosis 2.Systemically healthy individuals 3.Existence of a natural tooth in opposition 5. Adjacent teeth presence

Exclusion criteria

Exclusion criteria: 1.Individuals with compromised systemic health conditions that could impede bone healing and repair, such as diabetes mellitus, osteoporosis, blood problems. 2.Pregnant or lactating women 3.Heavy smokers or tobacco chewers 4.Patients with periodontal disease with severe attachment loss at the study site. 5.Sockets with complete loss of buccal/lingual cortical plate. 6.Radiotherapy and chemotherapy history 7.Poor oral hygiene and non-compliant patients

Design outcomes

Primary

MeasureTime frame
Clinical outcome of this study is to evaluate the width of the ridge following socket preservation using UNC-15 calibrated periodontal probe after 6 months. Radiographic outcome of the study is to measure the buccolingual and mesiodistal alveolar ridge width changes after 6 months using CBCT. Timepoint: Assessment will be done baseline and after 6 months

Secondary

MeasureTime frame
Clinical soft-tissue healing, including width of keratinized gingiva at the extraction site. To record any post-operative complications during the healing period. Timepoint: Assessment will be done baseline and after 6 months

Countries

India

Contacts

Public ContactDr Prasad V Dhadse

Datta Meghe Institute of Higher Education and Research (DU), Sawangi (Meghe) , Wardha

drprasaddhadse@gmail.com9822689401

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026