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A clinical study to compare the effects of preoperative nebulization of dexmedetomidine, ketamine and dexmedetomidine-ketamine combination in laparoscopic cholecystectomy patients undergoing general anaesthesia for postoperative pain

Comparison between the effects of dexmedetomidine, ketamine and dexmedetomidine-ketamine combination on postoperative pain under general anaesthesia in laparoscopic cholecystectomy patients: a prospective randomized controlled study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/110525
Enrollment
114
Registered
2026-05-12
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nebulization: Nebulization of dexmedetomidine Intervention2: Nebulization: Nebulization of ketamine Intervention3: Nebulization: Nebulization of a combination of dexmedetomidine and ket

Sponsors

Dr Kashmiri Rabha
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients giving informed written consent Patients undergoing an elective laparoscopic cholecystectomy procedure Ages 18-65 years ASA physical status I II

Exclusion criteria

Exclusion criteria: Patients refusing to give consent Any allergy to study drugs Body mass index more than 40 kg per m2 Raised intracranial and intraocular pressure Pregnant or lactating women Laparoscopic cholecystectomy converted to open cholecystectomy for any reason

Design outcomes

Primary

MeasureTime frame
To compare postoperative pain scoreTimepoint: 0 hours (immediate postoperative), 12 hours after surgery.—

Secondary

MeasureTime frame
Intraoperative hemodynamic parameters Quality of recovery Need for first-rescue analgesics Adverse effectsTimepoint: 0 hours (immediate postoperative), 3 hours, 6 hours, 12 hours, and 24 hours after surgery.—

Countries

India

Contacts

Public ContactDr Kashmiri Rabha

AIIMS Rishikesh

ajitdr.ajit@gmail.com9910789377

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026