Health Condition 1: N19- Unspecified kidney failure
Conditions
Interventions
Intervention1: Effect of Medium cut -off Extracorporeal dialysis on renal recovery in newly diagnosed myeloma cast nephropathy: A prospective observational study-: Medium cut off hemodialysis using MC
Sponsors
Postgraduate institute of Medical education and Research
Eligibility
Inclusion criteria
Inclusion criteria: 1.Newly diagnosed patients of multiple myeloma 2.AKI as per KDIGO criteria requiring initiation of dialysis 3.Probable or definite myeloma cast nephropathy: Definite: Kidney biopsy showing cast nephropathy Probable: AKI with markedly elevated absolute serum FLC levels (involved sFLC more than 500 mg/L; more than 1000 mg/L considered highly suggestive), minimal albuminuria, and absence of alternative causes of AKI 4.Who give informed consent
Exclusion criteria
Exclusion criteria: 1.AKI primarily due to causes other than myeloma (e.g., sepsis related ATN, obstructive uropathy, glomerulonephritis) 2.Advanced chronic kidney disease (baseline eGFR less than 15 mL/min/1.73 m prior to myeloma diagnosis) 3.Prior long term dialysis dependence 4.Hemodynamic instability precluding intermittent hemodialysis 5.Refusal to provide consent 6.Patients who have received prolonged (more than 72 hours or more than 3 sessions) of conventional high-flux hemodialysis before initiation of MCO dialysis will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Renal recovery as per International Myeloma Working Group (IMWG) renal response criteriaTimepoint: Renal recovery as per International Myeloma Working Group (IMWG) renal response criteria assessed at 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage reduction in sFLC levels Time to dialysis independence Patient survival at 3 months Timepoint: 3 months | — |
Countries
India
Contacts
Public ContactDrParul Bhardwaj
Postgraduate institute of Medical education and Research
Outcome results
None listed