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An intervention to compare pain reduction property of light-Activated methylene blue and Medicated Mouthwash in Treating Mouth Sores in participants undergoing Chemotherapy or Radiotherapy

Comparison of efficacy of one percentage methylene blue mediated photodynamic therapy and magic mouth wash in the management of radiotherapy and or chemotherapy induced oral mucositis A randomized controlled trial - NIL

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/110418
Enrollment
40
Registered
2026-05-12
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K123- Oral mucositis (ulcerative)

Interventions

Intervention1: 1% METHYLENE BLUE MEDIATED PHOTODYNAMIC THERAPY: 1% TOPICALLY APPLIED METHYLENE BLUE ACTIVATED BY LOW LEVEL LASER OF 640 NM IN THE SITE OF ORAL MUCOSITIS EVERY ALTERNATIVE DAYS Control

Sponsors

Dr Akshaya M
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with head and neck squamous cell carcinoma, undergoing chemotherapy and/or radiotherapy (with or without surgery), Presence of Grade I to III oral mucositis, Age more than or equal to 18 years, Willing to participate and comply with study protocol

Exclusion criteria

Exclusion criteria: Patients unwilling to participate Grade IV oral mucositis Patients with systemic conditions affecting healing (e.g., uncontrolled diabetes) Reduced mouth opening (less than 15 mm) Uncooperative patients

Design outcomes

Primary

MeasureTime frame
WHO Oral mucositis grading scale Oral Mucositis Assessment Scale (OMAS) VAS score PROMS questionnaireTimepoint: Day 0, 7, 15 30—

Secondary

MeasureTime frame
Oral microbial analysisTimepoint: Day 0, 30—

Countries

India

Contacts

Public ContactAKSHAYA M

HCG Cancer Hospitals

drakshayamurugan97@gmail.com9489158245

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026