Low-dose norepinephrine infusion helps maintain stable blood pressure safely in patients undergoing major surgery.

Efficacy and Safety of Low Concentration Nor-Epinephrine infusion in major surgery :A Randomised Controlled Study - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/110410

Enrollment

130

Registered

2026-05-12

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K639- Disease of intestine, unspecified

Interventions

Intervention1: Group NE:: Patients receiving norepinephrine 2.5mg diluted to 250ml normal saline started immediately after induction and continued throughout the surgery and 4 hours postoperatively Co

Eligibility

Inclusion criteria

Inclusion criteria: ASA classification 2 and 3 Age more than 18 years undergoing elective major abdominal or orthopaedic surgeries under General Anaesthesia Informed written and valid consent

Exclusion criteria

Exclusion criteria: Patients with preexisting severe untreated or uncontrolled hypertension Patient on irreversible nonselective MAO inhibitors within 2weeks of surgery Pregnant or breastfeeding mothers Patients having undergone CABG or PTCA in the last 6months Patients having Ejection fraction less than 40percent in 2D Echo

Design outcomes

Primary

Measure	Time frame
Incidence of intraoperative hypotensionTimepoint: Hemodynamic parameters were recorded every 3 minutes for the first 15 minutes following induction of anesthesia, followed by every 10 minutes for the next one hour, and thereafter every 30 minutes until completion of surgery	—

Secondary

Measure	Time frame
To compare the adverse drug event rates between the two groups 1 Drug extravasation leading to skin necrosis 2 Severe hypertension systolic BP more than 180mmhg 3 Tachyarrhythmias 4 Metabolic derrangements elevated lactate and hyperglycemiaTimepoint: Secondary outcomes like hemodynamic parameters were assessed at predefined intraoperative intervals-baseline,post-induction, 3 minutes and then every 15-30 minutes till the end of surgery.Post operative secondary outcomes were assessed over the first 4 hours every 30 minutes	—

Measure

Time frame

To compare the adverse drug event rates between the two groups 1 Drug extravasation leading to skin necrosis 2 Severe hypertension systolic BP more than 180mmhg 3 Tachyarrhythmias 4 Metabolic derrangements elevated lactate and hyperglycemiaTimepoint: Secondary outcomes like hemodynamic parameters were assessed at predefined intraoperative intervals-baseline,post-induction, 3 minutes and then every 15-30 minutes till the end of surgery.Post operative secondary outcomes were assessed over the first 4 hours every 30 minutes

—

Countries

India

Contacts

Public ContactDr Jyothi B

Karnataka Medial College and Research Institute

drjyothib1@gmail.com9886187056

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026