Comparing treatment to control brain pressure based on changes in blood and oxygen supply under anaesthesia in patients undergoing brain tumor surgery

Comparison of transcranial doppler (TCD)- and Near infrared spectroscopy (NIRS)-guided optimization of intracranial dynamics versus standard management for brain relaxation in supratentorial tumor surgery: A randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/110409

Enrollment

Registered

2026-05-12

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C719- Malignant neoplasm of brain, unspecified

Interventions

Intervention1: Algorithmic based management using transcranial doppler (TCD) and Near infrared spectroscopy (NIRS): Early institution of brain pressure lowering methods guided by transcranial doppler

Eligibility

Inclusion criteria

Inclusion criteria: 1.Supratentorial intraxial space occupying lesion surgery. 2.Preoperative imaging showing features of raised intracranial pressure

Exclusion criteria

Exclusion criteria: 1.Posterior fossa or skull base tumors. 2.Extraaxial lesions. 3.Inadequate TCD window. 4.Severe cardiopulmonary disease. 5.Significant anemia. 6.Prior craniotomy or skull defect near the insonation site. 7.Pregnancy. 8.Refusal to provide written informed consent.

Design outcomes

Primary

Measure	Time frame
To compare the brain relaxation score between the standard group and the intervention groupTimepoint: Measured once at baseline during surgery after the covering of the brain is exposed.	—

Secondary

Measure	Time frame
To compare rates of emergence agitation & postoperative delirium between groups.Timepoint: Immediate Postoperative;To compare the requirements of ICP reduction strategies between groups.Timepoint: End of surgery;To compare ICU & hospital length of stay between groups.Timepoint: At hospital discharge;To compare postoperative complications in terms of new onset neurological deficits & CT findings (edema, midline shift, infarct, hemorrhage)Timepoint: Post operative day 3	—

Measure

Time frame

To compare rates of emergence agitation & postoperative delirium between groups.Timepoint: Immediate Postoperative;To compare the requirements of ICP reduction strategies between groups.Timepoint: End of surgery;To compare ICU & hospital length of stay between groups.Timepoint: At hospital discharge;To compare postoperative complications in terms of new onset neurological deficits & CT findings (edema, midline shift, infarct, hemorrhage)Timepoint: Post operative day 3

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Countries

India

Contacts

Public ContactSudhir V

National Institute of Mental Health and Neurosciences

vsudhir77@gmail.com9900793108

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026