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Comparison of two methods of giving Tirofiban to improve heart blood flow during angioplasty in patients with acute heart problems.

COMPARATIVE EFFECTIVENESS OF INTRACORONARY PLUS INTRAVENOUS VERSUS INTRAVENOUS TIROFIBAN ON CLINICAL OUTCOMES IN PATIENTS WITH SLOW FLOW OR NO-REFLOW PHENOMENON DURING PERCUTANEOUS CORONARY INTERVENTION FOR ACUTE CORONARY SYNDROME - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/05/110392
Enrollment
250
Registered
2026-05-11
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I219- Acute myocardial infarction, unspecified

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil

Sponsors

MANIPAL ACADEMY OF HIGHER EDUCATION
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients aged 18 to 90 years with ACS undergoing PCI. 2.Development of slow or no-reflow (TIMI flow less than or equal to 2 or TIMI frame count more than 27) treated with tirofiban during PCI (intracoronary or intravenous).

Exclusion criteria

Exclusion criteria: 1.Active bleeding or contraindications to GP IIb/IIIa inhibitors. 2.Known allergy to tirofiban. 3.Mechanical complications of MI. 4.Procedural complications of MI.

Design outcomes

Primary

MeasureTime frame
TIMI flow CORRECTED TIMI FRAME COUNT Coronary microvascular function assessment from global longitudinal strain Timepoint: Pre and Post Procedure. Global longitudinal strain - Post procedure—

Secondary

MeasureTime frame
NILTimepoint: NIL—

Countries

India

Contacts

Public ContactDR UMESH PAI

MANIPAL COLLEGE OF HEALTH PROFESSIONS

umesh.pai@manipal.edu9449388828

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026