A rondomized prospective study to compare the time of reversal from neuromuscular blockade between two drugs sugammadex and neostigmine and after that compare the cognitive outcomes after extubation by giving these drugs in geriatric patient that are undergoing elective non cardiac surgery.

Comparision of sugammadex and neostigmine for reversal of neuromuscular blockade in geriatric patients undergoing elective surgery on recovery profiles and cogntive outcomes: A randomized prospective study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/110351

Enrollment

Registered

2026-05-11

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Sugammadex: We give Sugammadex ( 2mg/kg) intravenous aa reversal for neuromuscular blockade when the TOF count reaches 2 and note the time of administration to time of extubation and we

Eligibility

Inclusion criteria

Inclusion criteria: Patient of either sex with age 65 years and above for elective non cardiac surgery undergoinggeneral anesthesa with endotracheal intubation using vecuronium as neuromuscular blocking agent after taking written informed consent

Exclusion criteria

Exclusion criteria: Known any kind of allergy to study medication Severe renal or hepatic impairement Pre existing cognitive impairement Patient taking any antipsychotic and antidepressants medication

Design outcomes

Primary

Measure	Time frame
Total time from administration of reversal agent upto time of extubationTimepoint: 24 hours	—

Secondary

Measure	Time frame
To compare incidence of postoperative cognitive funtion assessed by Mini mental state examination at baselne(night before surger),2 hours,24 hours postoperativelyTimepoint: 24 hours;To compare the adverse effects in terms of bradycardia,hypotension,nausea and vomiting.Timepoint: 24 hours;To compare the incidence of residual neuromuscular blockade train of four ratio less than 0.9 in post anesthesia care unitTimepoint: 24 hours	—

Measure

Time frame

To compare incidence of postoperative cognitive funtion assessed by Mini mental state examination at baselne(night before surger),2 hours,24 hours postoperativelyTimepoint: 24 hours;To compare the adverse effects in terms of bradycardia,hypotension,nausea and vomiting.Timepoint: 24 hours;To compare the incidence of residual neuromuscular blockade train of four ratio less than 0.9 in post anesthesia care unitTimepoint: 24 hours

—

Countries

India

Contacts

Public ContactProf shefali gautam

King georges medical university

drshefalgautam@gmail.com9559468440

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026