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A study to see if high-dose PRP injections or Hyaluronic Acid injections work better for treating pain and stiffness caused by hip osteoarthritis

Effectiveness of ultrasound guided intra-articular injection of super dose of platelet-rich plasma (PRP) in comparison with high molecular weight hyaluronic acid in reducing pain and improving function in patients with hip osteoarthritis: a randomized controlled trial - NIL

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/110299
Enrollment
38
Registered
2026-05-10
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M169- Osteoarthritis of hip, unspecified

Interventions

Intervention1: Intraarticular injection of 8 ml super dose PRP: PRP will be prepared using Double spin method: 60 ml of whole blood will be obtained by venipuncture in acid citrate dextrose (ACD) tube
the supernatant plasma containing platelets will be collected and centrifuged again at hard spin i.e., 3600 rpm for 15 minutes to obtain a platelet concentrate. The lower 1/3rd is PRP and upper 2/3rd

Sponsors

Dr Manibhushan Yaikhom
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with primary hip osteoarthritis fulfilling 1991 American College of Rheumatology criteria for hip osteoarthritis. Duration of symptoms more than 3 months. KL Grade 2 and 3. VAS more than 4. People who are willing to participate in the study and comply with treatment and follow up assessments

Exclusion criteria

Exclusion criteria: Recent hip trauma or surgery. Infection of hip joint. Platelet count less than 180000/microliter. Metabolic disease of bone. BMI more than 30 kg/m2. Acute and chronic systemic infections. Coagulopathy and Bleeding disorders. Immunosuppressed patients (example HIV) Systemic disorders such uncontrolled diabetes or Malignancy Impaired cognition Recent use of steroid for hip pain within 3 months of the study

Design outcomes

Primary

MeasureTime frame
VAS score and HOOS scoreTimepoint: Baseline, 1 week, 4 week, 12 weeks and 24 weeks

Secondary

MeasureTime frame
NilTimepoint: Nil

Countries

India

Contacts

Public ContactDr Longjam Nilachandra Singh

Regional Institute of Medical Sciences

drnilalong@gmail.com7005018045

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026