Enhancing Postoperative Comfort Does Adding Magnesium to Epidural Fentanyl Improve Pain Control

Comparative study of single epidural bolus of Magnesium and Fentanyl versus Fentanyl alone for Postoperative Analgesia A Randomised Double Blind Study - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/110272

Enrollment

Registered

2026-05-10

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: SINGLE EPIDURAL BOLUS OF FENTANYL: Single drug use for postoperative analgesia for 24hours Control Intervention1: SINGLE EPIDURAL BOLUS OF MAGNESIUM AND FENTANYL: Dual drug use for post

Eligibility

Inclusion criteria

Inclusion criteria: American society of Anaesthesiologists Grade I/II Lower limb orthopaedic surgical procedures

Exclusion criteria

Exclusion criteria: Patients Refusal Morbidly obese Patients who had a past history of reaction to study drugs Patients on analgesic therapy and calcium channel blockers Patients having major hepatic, renal, or cardiovascular dysfunction Any contraindication to central neuraxial blockade

Design outcomes

Primary

Measure	Time frame
Adding magnesium sulfate to epidural fentanyl may improve postoperative analgesia, prolong its duration, and reduce opioid-related side effectsTimepoint: 24hrs	—

Secondary

Measure	Time frame
side effects like respiratory depression, sedation, urinary retention, nausea and vomiting, in both the groupsTimepoint: 24hrs	—

Countries

India

Contacts

Public ContactHarshitha BS

SNMC and HSK Hospital

drchhayajoshi@gmail.com9743320105

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026