Comparison of Bone Regeneration Using rhBMP-2 and Platelet-Rich Fibrin with Synthetic Bone Grafts in Periodontal Defects A Split-Mouth Study

- A comparative clinical and radiographic evaluation of using recombinant human bone morphogenetic protein 2 and platelet rich fibrin in combination with an alloplast in treating human intra bony defects A split mouth study.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/110266

Enrollment

Registered

2026-05-10

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: rhBMP-2 with Alloplast: patients treated with open flap debridement followed by rhBMP-2 with Alloplast and re-evaluate after 6 months Control Intervention1: Prf with Alloplast: patients

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy patients Minimum of probing pocket depth greater than or equal to 5 mm. Clinical attachment loss greater than or equal to 4mm. Depiction of angular defects in the intraoral periapical radiograph

Exclusion criteria

Exclusion criteria: Medically compromised patients Teeth with Grade III mobility and one wall defect Pregnant and lactating women Smokers Patients under medications

Design outcomes

Primary

Measure	Time frame
Reduction in pocket depth Clinical attachment gainTimepoint: Baseline 6 months	—

Secondary

Measure	Time frame
Gingival index Plaque indexTimepoint: Baseline 6 months	—

Countries

India

Contacts

Public ContactDr Harika Avanigadda

Sree Sai Dental College and Research Institute

anilkanc@gmail.com9989570600

Outcome results