Comparative study between neurolytic splanchnic plexus block and radio frequency ablation in patients of pancreatic cancer

Comparative study between neurolytic splanchnic plexus block and radio frequency ablation in patients of pancreatic cancer - nil

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/110257

Enrollment

Registered

2026-05-10

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K279- Peptic ulcer, site unspecified, unspecified as acute or chronic, without hemorrhage or perforation

Interventions

Intervention1: Radiofrequency ablation: Patients with pancreatic cancer suffering from refractory upper abdominal pain will be allocated to undergo either radiofrequency ablation (RFA) of the splanchn

Eligibility

Inclusion criteria

Inclusion criteria: Patients diagnosed with histologically confirmed pancreatic cancer and suffering from moderate to severe upper abdominal pain, quantified by a Visual Analog Scale (VAS) score of 7 or higher, are being addressed at the Pain Clinic in the department of anaesthesiology at KGMU, Lucknow. The patients have intractable abdominal pain that remains inadequately managed despite optimized treatments with opioids and adjuvant analgesics. Additionally, these patients present with an Eastern Cooperative Oncology Group (ECOG) performance status of 3 or lower.

Exclusion criteria

Exclusion criteria: Refusal of consent may occur due to several contraindications including coagulopathy or ongoing anticoagulant therapy, severe cardiopulmonary comorbidities that preclude intervention, local or systemic infections, and allergies to local anesthetics, alcohol, or phenol. Additionally, patients with cognitive impairments or psychiatric illnesses that affect their pain assessment may also refuse consent.

Design outcomes

Primary

Measure	Time frame
To compare the efficacy between neurolytic splanchnic plexus block and radio frequency ablation in patients of pancreatic cancerTimepoint: Baseline, 24 hours,1 week, 1 month, 3 months	—

Secondary

Measure	Time frame
Opioid consumption (oral morphine equivalent per day). Duration of effective analgesia. Quality of life assessment using EORTC QLQ-C30 questionnaire. Functional status (Karnofsky/ECOG score). Procedure-related complications (hypotension, neurological deficit, infection, diarrhea, etc.). Timepoint: Baseline, 24hours, 1 week, 1 month, 3 months	—

Countries

India

Contacts

Public ContactAAYUSHI MATHUR

King george medical university

acaa.mathur@gmail.com9051997682

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026