To compare the effects of intravenous Ondansetron or intravenous Granisetron on spinal anaesthesia induced hypotension in patients undergoing lower segment cesarean section.

Comparison of effects of Ondansetron and Granisetron on spinal anaesthesia induced hypotension in patients of lower segment caesarian section - A Randomized, controlled, double blinded study - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/110213

Enrollment

Registered

2026-05-08

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: To compare the amount of Injection Phenylephrine required to maintain Systolic Blood Pressure near baseline value in patients of LSCS under Subarachnoid block in three groups.: Total 60

Eligibility

Inclusion criteria

Inclusion criteria: Patients scheduled for LSCS under spinal anaesthesia ASA class two Age eighteen to thirty five years Height one hundred forty to one hundred seventy centimetres BMI less than thirty kg per metre square Uncomplicated singleton pregnancy Patients having systolic blood pressure between one hundred ten to one hundred thirty mm Hg

Exclusion criteria

Exclusion criteria: Patient having history of any systematic illness of cardiovascular system, respiratory system, endocrine, renal or hepatic disorders Patient taking any treatment for any chronic illness Fetal distress as diagnosed by obstetrician Patient having dehydration or antepartum haemorrhage BMI more than thirty kg per metre square

Design outcomes

Primary

Measure	Time frame
To compare the amount of injection phenylephrine required to maintain Systolic Blood Pressure near base line value of plus minus 20 percent in patients of LSCS under spinal anaesthesia in three groups that is Ondansetron group, Granisetron group and Placebo group.Timepoint: To compare the amount of injection phenylephrine required to maintain Systolic Blood Pressure near base line value of plus minus 20 percent in patients of LSCS under spinal anaesthesia in three groups that is Ondansetron group, Granisetron group and Placebo group.	—

Measure

Time frame

To compare the amount of injection phenylephrine required to maintain Systolic Blood Pressure near base line value of plus minus 20 percent in patients of LSCS under spinal anaesthesia in three groups that is Ondansetron group, Granisetron group and Placebo group.Timepoint: To compare the amount of injection phenylephrine required to maintain Systolic Blood Pressure near base line value of plus minus 20 percent in patients of LSCS under spinal anaesthesia in three groups that is Ondansetron group, Granisetron group and Placebo group.

—

Secondary

Measure	Time frame
To compare haemodynamic parameters (HR, SBP, DBP, MAP) To compare neonatal outcome by APGAR score at 1 min, 5 min and 10 min To compare pH, PaO2 and PaCO2 in blood of umbilical cord To compare the incidence of PONV in three groups.Timepoint: Till two hours post operative periods	—

Countries

India

Contacts

Public ContactDr Mahendra Kumar

School of Medical Sciences and Research Sharda University

mahendramohit@yahoo.com8287188449

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026