Health Condition 1: O098- Supervision of other high risk pregnancies
Conditions
Interventions
Intervention1: PARTIALLY HYDROLYSED GUAR GUM(6.2g/serve), SPLIT MEAL, FOOD ORDER ALONG WITH DIETARY COUNSELING BASED ON STANDARD CLINICAL GUIDELINE.: PHGG is a prebiotic soluble dietary fiber derived
Sponsors
University Grants Commission
Eligibility
Inclusion criteria
Inclusion criteria: OGTT Blood glucose value 2h PPPG greater than or equal to 140 mg per dl for experimental group. Blood glucose less than 140 mg per dl for genetic case control and interventional control group. Planning to attend the same tertiary care hospital for their rest of the pregnancy. All three trimesters Singleton pregnancy, primiparous, multiparous women, natural conception, pregnancies achieved through Assisted Reproductive Technology All classes of BMI Blood pressure category- normal systolic mm hg less than 120 and diastolic less than 80 mm hg elevated 120-129 and less than 80, stage 1 130-139 or 80-89. Willing to participate in the study.
Exclusion criteria
Exclusion criteria: Pre-existing diabetes : Type 1 & Type 2 Diabetes mellitus. Chronic hypertension, heart diseases, thyroid disorders, severe liver or kidney diseases (including intrahepatic cholestasis of pregnancy, autoimmune hepatitis, nephrotic syndrome, chronic glomerular nephritis, IgA nephropathy). Autoimmune disease (including systemic lupus erythematosus, rheumatoid arthritis, primary Sjogren syndrome), any chronic illness (cancer, tuberculosis), severely ill at commencement of the study. Medications that might affect their glucose metabolism steroids, beta-adrenergic agonist, anti- psychotic drugs)-can be a confounding factor for evaluating the effectiveness of the intervention. any gastrointestinal complications, Not willing to participate in the study. Previously given birth to child with in-born error metabolism. Bad obstetric history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.To evaluate the effect of a 2-week dietary intervention on blood glucose levels in pregnant women with gestational diabetes mellitus using Continuous Overall Net Glycemic action and Mean Amplitude of Glycemic Excursion calculations from Continuous Glucose Monitoring. 2. To Understand the prevalence of nuclear and mitochondrial mutations MT-TL1, TCF7L2, IRS1 through genetic testing among the women screened in the hospital, Chennai. 3. Correlation of Neck circumference , Triglyceride-glucose index with Gestation Diabetes Mellitus to predict it early.Timepoint: 2 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To assess the correlation between specific gene mutations with glycaemic response to dietary intervention. 2. To assess maternal and fetal outcomes in the participants 3. To assess maternal diabetic status after 3 month of delivery in the study group. Timepoint: 13 months | — |
Countries
India
Contacts
Public ContactS Tamil Malar
Meenakshi Academy of Higher Education and Research
Outcome results
None listed