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Comparison of three anaesthesia drug infusion techniques for pain relief after spinal surgery

Comparison of intraoperative ketamine-dexmedetomidine infusion versus fentanyl-dexmedetomidine infusion versus fentanyl infusion alone for postoperative analgesia following thoracolumbar spine surgeries: A randomized double-blind controlled trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/110199
Enrollment
90
Registered
2026-05-08
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G978- Other intraoperative and postprocedural complications and disorders of nervous system

Interventions

Intervention1: Ketamine + Dexmedetomidine: Intravenous Dexmedetomidine loading dose of 1 g/kg over 10 minutes after induction of anesthesia, followed by continuous infusion at 0.4 g/kg/hr. Intraveno

Sponsors

King George Medical University
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA Status 1 and 2 Thoracolumbar Spine surgeries Planned at two or more vertebral level

Exclusion criteria

Exclusion criteria: Non Consenting Allergy to study drugs Sensory defecit at level planned for surgeries Patient with raised Intracranial pressure

Design outcomes

Primary

MeasureTime frame
Time To First Rescue Analgesia in Postoperative PeriodTimepoint: After surgery—

Secondary

MeasureTime frame
Postoperative pain scores using Numeric rating scaleTimepoint: 0,2,4,8,12,24 hours;Total opioid consumptionTimepoint: First 24 hours—

Countries

India

Contacts

Public ContactRashmikant Singh Yadav

King George Medical University

hema2211@yahoo.co.in9415410236

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026