Study of how guided bacterial therapy and regular oral hygiene help keep the gums healthy around dental implants that are loaded early

Evaluation of the effect of Guided Microbial Colonization (GMC) with structured home care on peri-implant health in early loaded dental implants: A prospective randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/110186

Enrollment

Registered

2026-05-07

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Group A (n=17): Subjects with administration of Guided Microbial Colonization (GMC) at the time of implant placement, accompanied by structured home-care advocacy.: At baseline, patient

Eligibility

Inclusion criteria

Inclusion criteria: 1. Participants aged greater than 18 years will be included in the study. 2. Patients indicated for single-stage implant placement with early loading. 3. Adequate bone volume for implant placement without the need for augmentation 4. Willingness to participate and comply with follow-up visits

Exclusion criteria

Exclusion criteria: 1. Smokers or tobacco users. 2. Antibiotic or probiotic use within the last 3 months. 3. Pregnant or lactating women. 4. Known allergy to chlorhexidine or probiotic (Self-Reported). 5. Systemic diseases or conditions such as metabolic diseases, bone and haematological diseases, immunodeficiency, uncontrolled diabetes mellitus, kidney failure, tumor or radiation in the head and neck area or any other disease contraindicating implant placement. 6. Patients unwilling to complete the treatment protocol. 7. Patient with a history of allergic tendencies.

Design outcomes

Primary

Measure	Time frame
Microbial Metagenomic Analysis i.Relative abundance of microbiota ii.Microbial diversity iii.Dysbiosis index Clinical Evaluation including BOP, mPI, PD Patient-Reported Outcome Measures (PROMs) Timepoint: baseline,7 days,3 months and 6 months	—

Secondary

Measure	Time frame
Biochemical Parameters IL-1Beta,MMP 8 Radiographic Bone Levels Incidence of peri-implant mucositis Timepoint: baseline,7 days,3 months and 6 months	—

Countries

India

Contacts

Public ContactDr Gurparkash Singh Chahal

Dr Harvansh Singh Judge Institute of Dental Sciences and Hospital, Chandigarh

vishakha_grover@rediffmail.com9814277780

Outcome results