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A study comparing saline and lignocaine in the breathing tube cuff to reduce sore throat after surgery

Comparison of Normal Saline and Alkalinized 1.5 percent Lignocaine for Endotracheal Tube Cuff Inflation in Reducing Post-Intubation Morbidities: A Prospective Randomized Controlled Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/110121
Enrollment
80
Registered
2026-05-06
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Alkalinized 1.5% Lignocaine for ETT Cuff Inflation: Endotracheal tube (ETT) cuff will be inflated using 1.5% lignocaine alkalinized with 7.5% sodium bicarbonate in a 19:1 ratio. The sol

Sponsors

DR HET KHANDHAR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing elective surgery under general anesthesia lasting 2-4 hours.

Exclusion criteria

Exclusion criteria: - Patient s Refusal - Anticipated or unanticipated difficult airway - Smokers, pregnant women - Known allergy to study drugs - Respiratory comorbidities (asthma, COPD, chronic bronchitis) - Patients not extubated at the end of surgery - Surgery which can affect outcome such as thyroid surgery

Design outcomes

Primary

MeasureTime frame
Difference in the incidence and severity of postoperative sore throatTimepoint: at 0, 4, 8, 16, and 24 hours—

Secondary

MeasureTime frame
Difference in the incidence of postoperative complications like hoarseness and nausea/vomitingTimepoint: at 0, 4, 8, 16, and 24 hours;Difference in the composite smooth extubation score between two groupsTimepoint: during extubation—

Countries

India

Contacts

Public ContactDR NEETA BOSE

GMERS MEDICAL COLLEGE AND HOSPITAL

neetab2011@gmail.com9879521238

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026