Pain Relief After Leg Surgery:Comparing Different Epidural Medicines

Patient and provider reported outcome measures in patients undergoing lower limb orthopaedic surgeries comparing epidural adjuvants for postoperative analgesia in combined spinal epidural anaesthesia- An Observational study - Ease trail

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/110036

Enrollment

Registered

2026-05-05

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M958- Other specified acquired deformities of musculoskeletal system

Interventions

Intervention1: Comparing epidural adjuvants for postoperative analgesia in lower limb orthopaedics surgeries: To compare the duration of postoperative epidural analgesia between nalbuphine and dexmede

Eligibility

Inclusion criteria

Inclusion criteria: ASA I II Age 21 60 years Elective lower limb orthopedic surgeries Agree to participate

Exclusion criteria

Exclusion criteria: Allergy to study drugs Contraindication to neuraxial block Severe cardiac,renal,hepatic,neuro disease Drug abuse Refusal

Design outcomes

Primary

Measure	Time frame
To compare the duration of postoperative epidural analgesia between nalbuphine and dexmedetomidine when added to bupivacaine.Timepoint: On the day of surgery to 3rd postoperative day	—

Secondary

Measure	Time frame
To determine the Pain scores (VAS) over 48 hours,Number of top-up analgesic doses, Hemodynamic changes,Sedation levels,Adverse effects (bradycardia, hypotension, nausea, shivering) among these two adjuvants,Patient satisfaction scoresTimepoint: On the day of surgery to 3rd postoperative day	—

Countries

India

Contacts

Public ContactNeviya D

Madurai medical College and hospital

neviyadevarajan1997@gmail.com9629783363

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026