Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Dexmedetomidine: dexmedetomidine infusion at a dose of 0.5 mcg/kg/hour will be administered as an adjuvant to propofol based anaesthesia during minimally invasive surgery. Propofol infu
Sponsors
Mahatma Gandhi Medical College And Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Age 18 65 years All genders ASA Grade I and II Undergoing elective minimally invasive surgery.
Exclusion criteria
Exclusion criteria: Severe cardiovascular, renal, or hepatic disease. Chronic opioid or sedative use. BMI more than 35 kg/m . Any illness that prevents investigators to ask the QoR questions like neurological, psychological diseases 5. Pregnant or lactating female.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| quality of postoperative recovery assessed using QoR-15 score on postoperative day 1Timepoint: quality of postoperative recovery assessed using QoR-15 score on postoperative day 1 | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain intensity assessed using Visual Analogue Scale (VAs)Timepoint: At 1, 6, 12 and 24 hours postoperatively ;Changes in heart rate and mean arterial pressure during intraoperative periodTimepoint: aseline, intraoperatively at 1 , 3 , 5 , 10 , 15 minutes and then regularly at 15 minutes interval ;Time to achieve Aldrete score more than 9 after discontinuation of infusion Timepoint: From switching off infusion until achievement of Aldrete score more than 9 in the postoperative period;Level of sedation assessed using Ramsay Sedation ScoreTimepoint: Intraoperatively and in the immediate postoperative period ;Total postoperative rescue analgesic requirement in first 24 hours Timepoint: Within 24 hours postoperatively ;Incidence of adverse effects such as hypotension, bradycardia, respiratory depression, nausea and vomitingTimepoint: Intraoperative and within 24 hours postoperatively;Total propofol requirement during surgeryTimepoint: From induction to completion of surgery;Time to first ambulation postoperativelyTimepoint: From end of surgry to first ambulation;Time to extubation after discontinuation of anaesthetic agentsTimepoint: From stopping anaesthetic agents to tracheal extubation | — |
Countries
India
Contacts
Public ContactDr vijay mathur
Mahatma Gandhi Medical College And Hospital
Outcome results
None listed