Comparison of lidocaine five percent patch and capsaicin zero point zero seven five percent patch for pain relief in post herpetic neuralgia

A Comparative Study to Evaluate the Efficacy of Lidocaine 5 percent Patch versus Capsaicin 0.075 percent Patch in Postherpetic Neuralgia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/109973

Enrollment

Registered

2026-05-04

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B022- Zoster with other nervous system involvement

Interventions

Intervention1: Lidocaine five percent topical patch: apply to the most painful area for 12 hours Control Intervention1: Capsaicin zero point zero seven five percent topical patch: apply to the most pa

Eligibility

Inclusion criteria

Inclusion criteria: Adults with confirmed clinical diagnosis of post herpetic neuralgia involving thoracolumbar dermatomes. Baseline Numerical Rating Scale pain score 4 or more. Able to provide written informed consent and comply with study procedures. Regular use of neuropathic medicines such as gabapentin for at least 2 weeks before intervention.

Exclusion criteria

Exclusion criteria: Active skin infection or open wound at the application site. Skin hypersensitivity or allergy to lidocaine or capsaicin. Concurrent use of other topical analgesics. Severe cognitive impairment or inability to complete pain and quality of life assessments. Significant comorbidities that may confound study outcomes. Pregnancy, breastfeeding, or unwillingness to use contraception if applicable

Design outcomes

Primary

Measure	Time frame
Reduction in pain intensity measured by Numerical Rating Scale (NRS 0-10)Timepoint: Baseline, 2 hours, 12 hours, 24 hours, 48 hours, and 72 hours post-intervention	—

Secondary

Measure	Time frame
Adverse effects of intervention (erythema, burning sensation, pruritus and others) assessed by description, severity (CTCAE Grade 1-5), relatedness to treatment, and action takenTimepoint: 2 hours, 12 hours, 24 hours, 48 hours, and 72 hours post-intervention;Patient satisfaction and feedback using 5-point Likert scale (1-5) for pain relief effectiveness, side effects tolerability, overall satisfaction, and willingness to recommend treatmentTimepoint: 72 hours post-intervention;Quality of life assessed by EuroQol-5D-5L Index (0-1) and EQ-VAS (0-100)Timepoint: Baseline and 72 hours post-intervention	—

Measure

Time frame

Adverse effects of intervention (erythema, burning sensation, pruritus and others) assessed by description, severity (CTCAE Grade 1-5), relatedness to treatment, and action takenTimepoint: 2 hours, 12 hours, 24 hours, 48 hours, and 72 hours post-intervention;Patient satisfaction and feedback using 5-point Likert scale (1-5) for pain relief effectiveness, side effects tolerability, overall satisfaction, and willingness to recommend treatmentTimepoint: 72 hours post-intervention;Quality of life assessed by EuroQol-5D-5L Index (0-1) and EQ-VAS (0-100)Timepoint: Baseline and 72 hours post-intervention

—

Countries

India

Contacts

Public ContactDr Nazish Hussain

Jawaharlal Nehru Medical College, Aligarh Muslim University

hammadusmani2002@gmail.com9897114190

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026