Comparison of Short duration and Standard Caffeine Therapy in terms of Efficacy

Comparative study to establish the efficacy of short duration caffeine therapy with conventional regimen - SHORT-CAF Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/109971

Enrollment

100

Registered

2026-05-04

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: P284- Other apnea of newborn

Interventions

Intervention1: Discontinuation of caffeine therapy after apnea free inteval of 7 days: This is the proposed duration of caffeine therapy where caffeine is stopped after apnea free interval of 7 days C

Eligibility

Inclusion criteria

Inclusion criteria: Neonates greater than 30 weeks of gestational age with apnea of prematurity whose parents are consenting for the study

Exclusion criteria

Exclusion criteria: 1. Neonates with other explanations for apneic episodes such as sepsis , hypoglycemia , hypothermia , hypocalcemia ,pernatal asphyxia , maternal drug usage 2. Neonates with congenital malformations . 3. Neonates with any suspected metabolic syndromes .

Design outcomes

Primary

Measure	Time frame
Recurrence of apnea of prematurity after discontinuation of caffeine therapyTimepoint: Within 5 days after discontinuation of caffeine therapy	—

Secondary

Measure	Time frame
Frequency of apnea episodes during theapyTimepoint: Baseline , Day 3, Day 7 & till discontinuation;Successful apnea free period before stopping caffeine (7 consecutive days without apnea )Timepoint: During therapy;Need for respiratory support (CPAP / Mechanical Ventilation )Timepoint: During hospital stay;Duration of hospital stayTimepoint: At discharge;Adverse effects of caffeine ( tachycardia , feeding intolerance , jitteriness )Timepoint: Daily during therapy till discontinuation	—

Measure

Time frame

Frequency of apnea episodes during theapyTimepoint: Baseline , Day 3, Day 7 & till discontinuation;Successful apnea free period before stopping caffeine (7 consecutive days without apnea )Timepoint: During therapy;Need for respiratory support (CPAP / Mechanical Ventilation )Timepoint: During hospital stay;Duration of hospital stayTimepoint: At discharge;Adverse effects of caffeine ( tachycardia , feeding intolerance , jitteriness )Timepoint: Daily during therapy till discontinuation

—

Countries

India

Contacts

Public ContactDr Satvik Bansal

Kamla Raja Hospital , JAH Hospital campus ,

drsatvikbansal@gmail.com9425112777

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026