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Postoperative cognitive deficit with propofol infusion in neurosurgery patients.

Correlation of Intraoperative Bi-spectral index (BIS) values and Serum Propofol Levels with Postoperative Cognitive Dysfunction in the Elderly patients undergoing Neurosurgical procedures under Total Intravenous Anaesthesia: Prospective Observational Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/05/109945
Enrollment
100
Registered
2026-05-04
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G969- Disorder of central nervous system, unspecified

Interventions

Control Intervention1: Nil: Nil

Sponsors

AIIMS Jodhpur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Study will involve patients of either gender, aged between 60 and 75 years, ASA I-III who are undergoing elective neurosurgical procedures under total intravenous anaesthesia (TIVA) using propofol

Exclusion criteria

Exclusion criteria: 1. Pre-existing cognitive impairments. 2. Other than Neurological or psychiatric disorders. 3. Patients requiring prolonged mechanical ventilation 4. Inability to complete neurocognitive assessments 5. Use of medications affecting cognitive function. 6. History of allergy to propofol and any other contraindications

Design outcomes

Primary

MeasureTime frame
To evaluate the correlation between intraoperative BIS values and incidence of POCD during elective neurosurgical proceduresTimepoint: 1.before induction (baseline) 2.2nd min after propofol administration during induction 3.30th min after starting propofol infusion 4.2 hours after starting propofol infusion 5.At the end of surgery—

Secondary

MeasureTime frame
1. To evaluate the correlation between serum propofol levels and incidence of POCD during elective neurosurgical proceduresTimepoint: 1. before induction (baseline) 2. 2nd min after propofol administration during induction 3. 30th min after starting propofol infusion 4. 2 hours after starting propofol infusion 5. At the end of surgery ;2. To evaluate the association between intraoperative BIS values, serum propofol levels, and the incidence of POCDTimepoint: 1. before induction (baseline) 2. 2nd min after propofol administration during induction 3. 30th min after starting propofol infusion 4. 2 hours after starting propofol infusion 5. at the end of surgery ;3. Frequency of CYP2B6 516G T and 785A G polymorphismTimepoint: At baseline—

Countries

India

Contacts

Public ContactShoban Babu Varthya

AIIMS Jodhpur

drshobanpgimer@gmail.com8437726777

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026