Study comparing injection methods of dexamethasone to reduce pain, swelling and difficulty in mouth opening after wisdom tooth surgery

Comparative evaluation of preoperative and postoperative intramuscular vs. intravenous dexamethasone on postoperative sequelae following surgical removal of impacted mandibular third molar: a randomized controlled trial. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/109939

Enrollment

110

Registered

2026-05-04

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Dexamethasone (Intramuscular, Preoperative): Single dose (8 mg) dexamethasone administered intramuscularly 30 minutes prior to surgery (one- time administration) Intervention2: Dexameth

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients belonging to the age category of 18-60 years. 2. Patient with ASA - 1 Category 3. Patients indicated for surgical extraction of mandibular impacted third molars 4. Patients with impacted mandibular third molars of moderate to high difficulty level based on Pederson difficulty index. 5. Patients willing to provide informed consent 6. Patients having normal blood parameters as per lab investigations.

Exclusion criteria

Exclusion criteria: 1. Patients who are not willing to participate or give consent for the study 2. Pregnant or lactating female patients 3. Patients who are immunocompromised or suffering from systemic disorders contraindicating steroid use. 4. Patients allergic to dexamethasone. 5. Patients on anti coagulant drugs.

Design outcomes

Primary

Measure	Time frame
Postoperative facial swelling measured using linear facial measurements between anatomical landmarksTimepoint: 3rd postoperative day and 7th postoperative day	—

Secondary

Measure	Time frame
Postoperative pain assessed using Visual Analogue Scale (VAS)Timepoint: 3rd postoperative day and 7th postoperative day;Trismus assessed by maximum interincisal mouth opening (in cm)Timepoint: 3rd postoperative day and 7th postoperative day	—

Countries

India

Contacts

Public ContactYojana Gupta

KLE academy of higher education and research

Kotra27@gmail.com9448116959

Outcome results