Health Condition 1: R112- Nausea with vomiting, unspecified
Conditions
Interventions
Intervention1: Ondansetron: Ondansetron Dose 4mg administered intravenously Duration 5 minutes before extubation for prevention of postoperative nausea and vomiting.Frequency once
Control Intervention
Sponsors
Lance Joseph Martin
Eligibility
Inclusion criteria
Inclusion criteria: Age 18 60 years Either gender ASA physical status I or II Elective surgery under general anaesthesia Expected postoperative hospital stay of 24 hours or more Ability to understand study procedure Written informed consent
Exclusion criteria
Exclusion criteria: Drug-related Hypersensitivity to Ondansetron or Granisetron Antiemetic use within 24 hours Patient-related Pregnancy or lactation ASA Physical Status Grade III or above GI or neurological disorders affecting PONV Surgical or Perioperative Emergency surgeries ICU or ventilation requirement Others Refusal or withdrawal Incomplete data
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete response within 24 hours postoperatively, defined as absence of nausea, vomiting/ retching, and no requirement of rescue antiemetic.Timepoint: 0 2 hours, 2 6 hours, and 6 24 hours postoperatively. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1 Incidence of PONV 2 Severity of PONV using RINVR score (0 32) 3 Time to first episode of PONV 4 Requirement and timing of rescue antiemetic 5 Incidence of adverse effects (headache, dizziness, constipation) 6 Patient satisfaction assessed using Likert scaleTimepoint: 0 2 hours, 2 6 hours, and 6 24 hours postoperatively. | — |
Countries
India
Contacts
Public ContactLance Joseph Martin
PRAKASH INSTITUTE OF MEDICAL SCIENCES AND RESEARCH
Outcome results
None listed