Comparing Standard Practice with Scientific Equipment to Predict the Most Appropriate Time to Insert Tube in the Airway

Comparing Standard Time Versus Train of Four Based Time to Intubation With Non Depolarizing Muscle Relaxants to Predict Optimal Time for Intubation: An Exploratory study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/109935

Enrollment

200

Registered

2026-05-04

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: TOF based time to intubation: Intubation after achieving a Train of four count of zero Control Intervention1: Standard time to intubation: Conventionally used fixed time of 3 minutes fo

Eligibility

Inclusion criteria

Inclusion criteria: All patients 18 to 80 years of age Of either sex Requiring neuromuscular blockade for elective surgical procedure

Exclusion criteria

Exclusion criteria: Refusing consent MMPS more than or equal to 3 Pre-existing neuromuscular disorder CNS disorders

Design outcomes

Primary

Measure	Time frame
To compare the haemodynamic stress response (change in heart rate from baseline to one minute after intubation) in standard group versus TOF based groupTimepoint: Baseline One minute after intubation	—

Secondary

Measure	Time frame
To compare the change in blood pressure from baseline to one minute after intubation between the two groupsTimepoint: Baseline One minute after intubation;To compare the standard time with the time taken for Train of four count to become zero from the administration of the neuromuscular blocking drug (t=0 mins)Timepoint: Three minutes Time taken for TOF count to become zero;To compare the two groups in terms of the CL view at the time of intubation, mean duration of laryngoscopy and intubation.Timepoint: Time of intubation Mean duration of laryngoscopy and intubation;To study the patient variables (age, weight, sex, BMI, comorbidities, temperatute) affecting the TOF count with different neuromuscular blocking agents.Timepoint: Baseline Time taken for TOF count to become zero;To study the incidence of sore throat, coughing, change of voice, after extubation in two groups.Timepoint: After extubation	—

Measure

Time frame

To compare the change in blood pressure from baseline to one minute after intubation between the two groupsTimepoint: Baseline One minute after intubation;To compare the standard time with the time taken for Train of four count to become zero from the administration of the neuromuscular blocking drug (t=0 mins)Timepoint: Three minutes Time taken for TOF count to become zero;To compare the two groups in terms of the CL view at the time of intubation, mean duration of laryngoscopy and intubation.Timepoint: Time of intubation Mean duration of laryngoscopy and intubation;To study the patient variables (age, weight, sex, BMI, comorbidities, temperatute) affecting the TOF count with different neuromuscular blocking agents.Timepoint: Baseline Time taken for TOF count to become zero;To study the incidence of sore throat, coughing, change of voice, after extubation in two groups.Timepoint: After extubation

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Countries

India

Contacts

Public ContactDr Anirban Brahma Adhikary

All India Institute of Medical Sciences, Rishikesh

anirbanadhikary84@gmail.com08486241661

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026