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COMPARISON OF NLRP3 AND MATRIX METALLOPROTEINASE-9 IN GINGIVAL CREVICULAR FLUID LEVELS IN PATIENTS WITH PULP NECROSIS AND SYMPTOMATIC APICAL PERIODONTITIS

Comparison of nlrp3 and matrix metalloproteinase-9 in gingival crevicular fluid levels in patients with pulp necrosis and symptomatic apical periodontitis - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/109931
Enrollment
33
Registered
2026-05-04
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: patient diagnosed with pulp necrosis and symptomatic apical periodontitis.: patient diagnosed with pulp necrosis and symptomatic apical periodontitis. Control Intervention1: Healthy ind

Sponsors

Riya Gupta
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1)Patients diagnosed with pulp necrosis and symptomatic apical periodontitis in mandibular molar. 2)Patients aged 18-40 years of age 3)Patients with no relevant medical history or absence of any systemic conditions 4)Non-smokers

Exclusion criteria

Exclusion criteria: 1)Patients with periodontitis 2)Patients with multiple carious teeth 3) Patients with apical abscess (swelling) &/or sinus tract.

Design outcomes

Primary

MeasureTime frame
The NLRP3 and MMP-9 levels in GCF may increase and hence detectable in patients with pulp necrosis and symptomatic apical periodontitis but will reduce after endodontic treatment.Timepoint: 1, 3, and 6 months—

Secondary

MeasureTime frame
NILTimepoint: NIL—

Countries

India

Contacts

Public ContactMonika Tandan

Manav Rachna Dental College

daxabraham.sds@mrei.ac.in9910433111

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026