A study on the effects of Remifentanil and Fentanyl on haemodynamic parameters of patients undergoing breast surgeries and on post-operative recovery.

Comparing the effects of Remifentanil and Fentanyl on intraoperative haemodynamic parameters and on post-operative recovery in breast surgeries : a prospective study. - nil

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/109908

Enrollment

Registered

2026-05-04

Start date

Unknown

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C509- Malignant neoplasm of breast of unspecified site

Interventions

Intervention1: inj. Remifentanil: loading dose - 2mcg/kg bolus dose using infusion pump in 1 min maintainance dose - 0.2mcg/kg/min using infusion pump till the end of surgery duration of action- 3-10

Eligibility

Inclusion criteria

Inclusion criteria: Patient giving informed consent, Patient planned for elective breast surgeries, ASA Physical score 1, 2, and 3.

Exclusion criteria

Exclusion criteria: Patient with chronic opioid addiction, Patient with known hypersensitivity to studied drugs, BMI more than 35kg/m2, Anticipated difficult intubation

Design outcomes

Primary

Measure	Time frame
To compare the effects of remifentanil and fentanyl on intraoperative haemodynamic parameters and on post-operative recovery in breast surgeries.Timepoint: On the day of surgery, patient was connected to multiparameter monitors according to the ASA protocols and baseline vitals were noted and patient was induced with standard protocols of general anesthesia with, Patient were infused with iv inj. Remifentanil 2mcg/kg over 60 seconds via infusion pump followed by inj. Remifentanil 0.25mcg/kg/minute infusion till the end of surgery or Patient were infused with iv inj. Fentanyl 2mcg/kg over 60 seconds via infusion pump followed by inj. Fentanyl 0.025mcg/kg/minute infusion till the end of surgery . The patients were maintained on general anaesthesia as per standard institutional protocol and intra op monitoring was done.	—

Measure

Time frame

To compare the effects of remifentanil and fentanyl on intraoperative haemodynamic parameters and on post-operative recovery in breast surgeries.Timepoint: On the day of surgery, patient was connected to multiparameter monitors according to the ASA protocols and baseline vitals were noted and patient was induced with standard protocols of general anesthesia with, Patient were infused with iv inj. Remifentanil 2mcg/kg over 60 seconds via infusion pump followed by inj. Remifentanil 0.25mcg/kg/minute infusion till the end of surgery or Patient were infused with iv inj. Fentanyl 2mcg/kg over 60 seconds via infusion pump followed by inj. Fentanyl 0.025mcg/kg/minute infusion till the end of surgery . The patients were maintained on general anaesthesia as per standard institutional protocol and intra op monitoring was done.

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Secondary

Measure	Time frame
To compare the ease of extubation in terms of coughing and buckingTimepoint: On the day of surgery, patient was connected to multiparameter monitors according to the ASA protocols and baseline vitals were noted and patient was induced with standard protocols of general anesthesia with, Patient were infused with iv inj. Remifentanil 2mcg/kg over 60 seconds via infusion pump followed by inj. Remifentanil 0.25mcg/kg/minute infusion till the end of surgery or Patient were infused with iv inj. Fentanyl 2mcg/kg over 60 seconds via infusion pump followed by inj. Fentanyl 0.025mcg/kg/minute infusion till the end of surgery . The patients were maintained on general anaesthesia as per standard institutional protocol and intra op monitoring was done.;To compare the adverse effects if any. Timepoint: On the day of surgery, patient was connected to multiparameter monitors according to the ASA protocols and baseline vitals were noted and patient was induced with standard protocols of general anesthesia with, Patient were infused with iv inj. Remifentanil 2mcg/kg over 60 seconds via infusion pump followed by inj. Remifentanil 0.25mcg/kg/minute infusion till the end of surgery or Patient were infused with iv inj. Fentanyl 2mcg/kg over 60 seconds via infusion pump followed by inj. Fentanyl 0.025mcg/kg/minute infusion till the end of surgery . The patients were maintained on general anaesthesia as per standard institutional protocol and intra op monitoring was done.	—

Measure

Time frame

To compare the ease of extubation in terms of coughing and buckingTimepoint: On the day of surgery, patient was connected to multiparameter monitors according to the ASA protocols and baseline vitals were noted and patient was induced with standard protocols of general anesthesia with, Patient were infused with iv inj. Remifentanil 2mcg/kg over 60 seconds via infusion pump followed by inj. Remifentanil 0.25mcg/kg/minute infusion till the end of surgery or Patient were infused with iv inj. Fentanyl 2mcg/kg over 60 seconds via infusion pump followed by inj. Fentanyl 0.025mcg/kg/minute infusion till the end of surgery . The patients were maintained on general anaesthesia as per standard institutional protocol and intra op monitoring was done.;To compare the adverse effects if any. Timepoint: On the day of surgery, patient was connected to multiparameter monitors according to the ASA protocols and baseline vitals were noted and patient was induced with standard protocols of general anesthesia with, Patient were infused with iv inj. Remifentanil 2mcg/kg over 60 seconds via infusion pump followed by inj. Remifentanil 0.25mcg/kg/minute infusion till the end of surgery or Patient were infused with iv inj. Fentanyl 2mcg/kg over 60 seconds via infusion pump followed by inj. Fentanyl 0.025mcg/kg/minute infusion till the end of surgery . The patients were maintained on general anaesthesia as per standard institutional protocol and intra op monitoring was done.

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Countries

India

Contacts

Public ContactDr Deepali Valecha

Mahatma Gandhi Memorial Medical College Indore, IN

deepalisidhwani@gmail.com9424405405

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026