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Which works better to reduce brain pressure in stroke - saline or mannitol using an eye based measurement

Comparison of 3% saline with 20% mannitol in lowering the elevated intracranial pressure in stroke patients by using optic nerve sheath diameter - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/109889
Enrollment
70
Registered
2026-05-04
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: 3% Hypertonic Saline ICP reduction: injection 3% hypertonic saline 2ml/kg iv bolus Control Intervention1: 20% Mannitol ICP Reduction: injection mannitol 20% 1g/kg iv bolus

Sponsors

Safdarjung Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ONSD MORE THAN 5.5mm

Exclusion criteria

Exclusion criteria: TBI SAH

Design outcomes

Primary

MeasureTime frame
To compare 3% hypertonic saline with 20% mannitol in lowering the ICP in stroke patientsTimepoint: 0, 30, 60, 90 minutes—

Secondary

MeasureTime frame
To compare 3% hypertonic saline with 20% mannitol in lowering the ICP in stroke patients using ONSDTimepoint: Baseline, 30 minutes, 60 minutes, 90 minutes;To correlate NCCT findings of raised ICP in all clinically diagnosed acute stroke patients with increased ONSDTimepoint: 6 hours;To assess the day-7 cognitive improvement using GCSTimepoint: Week 1—

Countries

India

Contacts

Public ContactAshiqui S Mohammed

VMMC and Safdarjung Hospital

sanjaynaiding@yahoo.in9313584384

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026