A study to compares surgery verus a medicated cream to see which works better for treating a painful anal tear.

Comparative Study of Open lateral internal Sphincterotomy and 2 percent Diltiazem Gel as Local Application in the Treatment of Acute fissure in ano - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/109878

Enrollment

130

Registered

2026-04-30

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Open Lateral Internal Sphincterotomy: Open Lateral Internal Sphincterotomy will be done in cases of acute anal fissure. Total duration of intervention will be 6 weeks. Control Intervent

Eligibility

Inclusion criteria

Inclusion criteria: 1.Diagnosed with acute fissure in ano 2.Willing to provide informed consent

Exclusion criteria

Exclusion criteria: 1. Previous anal surgery 2. Known allergy or contraindication to diltiazem 3. Immunocompromised patient 4. Recurrent fissure 5. Fissure associated with tuberculosis 6. Fissure associated with haemorrhoids, fistula

Design outcomes

Primary

Measure	Time frame
Fissure Healing Rate will be better with local application of 2% of diltiazem gel Timepoint: Assessment will be done at 2, 4, and 6 weeks post-treatment.	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Rajesh Gattani

Datta Meghe Institute of Higher Education and Research

sakshigattani@gmail.com9373108181

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026