Health Condition 1: K031- Abrasion of teeth
Conditions
Interventions
Intervention1: Selcopintide: Selcopintide (Cpne7-DP) consists of a synthetic peptide corresponding to the 10 amino acid residue 344-353 fragment of the hCPNE7 protein. Selcopintide highly reproduces t
Sponsors
VIJAY KUMAR JILLELLA
Eligibility
Inclusion criteria
Inclusion criteria: 1. Participants will be aged between 20 years and 70 years. 2. Participants will be able to provide written informed consent. 3. Participants will be confirmed as healthy by the examiner, without clinically significant diseases that can interfere with the study outcomes. 4. Participants will have more than two sensitive teeth with dentin exposure due to gingival recession, abrasion, or attrition.
Exclusion criteria
Exclusion criteria: 1. Individuals who received treatment for DH within the past 4 weeks 2. Individuals who had teeth with DH due to other reasons (e.g., dental caries and defective restorations) 3. Individuals who had taken nonsteroidal anti-inflammatory drugs or narcotic analgesics within the past week 4. Individuals with clinically significant allergic diseases 5. Pregnant or lactating women 6. Smokers 7. Individuals who used toothpaste specifically designed for treating DH in the past 4 weeks 8. Individuals who may have undergone teeth bleaching treatment within the past 4 weeks 9. Individuals who underwent scaling or periodontal treatment within the past 4 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate and compare the reduction in dentinal hypersensitivity achieved using a Selcopintide incorporated bonding agent and G-Bond, assessed by the Visual Analog Scale (VAS), Schiff score, air and coldTimepoint: Before the treatment and followed by 2 weeks after treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To assess the change in dentinal hypersensitivity over time following application of both bonding agents. 2. To compare evaporative air sensitivity between the test and control groups using the Schiff sensitivity score. 3. To assess patient-reported comfort following application of both bonding agents. Timepoint: Before the treatment and followed by 2 weeks after treatment | — |
Countries
India
Contacts
Public ContactDR SWAPNA SANNAPUREDDY
NARAYANA DENTAL COLLEGE AND HOSPITAL, NELLORE
Outcome results
None listed