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Study of the relationship between autonomic nervous system changes and walking capacity in individuals with Grade I hypertension

Correlation of autonomic changes assessed by heart rate variability with functional capacity measured by six-minute walk distance in Grade I hypertensive individuals: A cross-sectional observational study - WALK-HRV HTN

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/04/109833
Enrollment
123
Registered
2026-04-30
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I00-I99- Diseases of the circulatory system

Interventions

Intervention1: Nil: Nil

Sponsors

Dr. D. Y. Patil college of Physiotherapy
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Individuals diagnosed with Grade I hypertension, with systolic blood pressure between 140 159 mmHg and/or diastolic blood pressure between 90 99 mmHg, according to International Society of Hypertension guidelines. Male and female participants aged 45 59 years. Individuals with 6-minute walk distance less than 80% of predicted value. Participants who are willing to participate and provide written informed consent.

Exclusion criteria

Exclusion criteria: Individuals with a history of smoking, alcohol consumption, or tobacco chewing. Individuals with known metabolic, respiratory, renal, or systemic disorders, such as: Obesity Diabetes mellitus Chronic obstructive pulmonary disease (COPD) Kidney disorders Anemia Individuals with any neurological or psychiatric conditions affecting participation. Individuals with musculoskeletal or orthopedic conditions affecting walking capacity, such as: Recent lower limb fracture Osteoarthritis of knee Recent lower limb surgery Prolapsed intervertebral disc (PIVD) Inflammatory joint conditions Individuals with spinal or lower limb deformities that affect gait, such as scoliosis, kyphosis, or equinus deformity. Individuals with cardiovascular conditions other than Grade I hypertension that may influence autonomic function or exercise capacity.

Design outcomes

Primary

MeasureTime frame
Primary Outcome Measure Heart Rate Variability (HRV) assessed using time domain and frequency domain parameters to determine autonomic changes in Grade I hypertensive individualsTimepoint: Baseline assessment (single assessment)—

Secondary

MeasureTime frame
Functional capacity assessed using Six-Minute Walk Distance (6MWD) in Grade I hypertensive individualsTimepoint: Baseline assessment (single assessment)—

Countries

India

Contacts

Public ContactDr Mayuri Shah

Dr. D.Y. Patil college of Physiotherapy

mayuri.shah@dpu.edu.in8087861628

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026