Comparison of Two Drugs for Pain Relief and Recovery in Patients Undergoing Keyhole Gallbladder Surgery

Comparison of dexmedetomidine versus remifentanyl in postoperative analgesia and recovery profile of patients undergoing laparoscopic cholecystectomy - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/109805

Enrollment

100

Registered

2026-04-30

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis

Interventions

Intervention1: Dexmedetomidine: Group D will receive IV dexmedetomidine 1 g/kg loading dose for 10 minutes, followed by continuous infusion of 0.1 g/kg/hr till the completion of surgery. All patients

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with age 18-60 years 2. Gender (both males and females) 3. American Society of Anaesthesiologists (ASA) grade I and II

Exclusion criteria

Exclusion criteria: 1. Refusal by the patient 2. Patients with history of allergy to study drugs 3. Patients with American Society of Anaesthesiologists (ASA) grade III or more 4. Morbid obesity 5. Pregnant and lactating patient 6. Renal and Hepatic insufficiency 7. Chronic use of analgesic or any other chronic drug therapy 8. Coagulation disorder 9. Alcohol or opioid abuse 10. History of psychiatric or neurological disease 11. History of hypotension, bradycardia, atrioventricular block

Design outcomes

Primary

Measure	Time frame
1. Postoperative analgesia by Visual Analog Scale 2. Level of Sedation by Observer Assessment of Alertness/Sedation Scale 3. Patient Satisfaction ScoreTimepoint: 1. Pain will be assessed in postoperative period by VAS score at 0 hour (immediately post op), 1 hour, 2 hours, 4 hours, 8 hours, 12 hours, 18 hours and 24 hours 2. Level of Sedation by Observer Assessment of Alertness/Sedation Scale (sedation score) at 0 hour (immediately post op), 1 hour, 2 hours, 4 hours, 8 hours, 12 hours, 18 hours and 24 hours post op 3. Patient Satisfaction Score at 0 hour (immediately post op), 1 hour, 2 hours, 4 hours, 8 hours, 12 hours, 18 hours and 24 hours post op	—

Measure

Time frame

1. Postoperative analgesia by Visual Analog Scale 2. Level of Sedation by Observer Assessment of Alertness/Sedation Scale 3. Patient Satisfaction ScoreTimepoint: 1. Pain will be assessed in postoperative period by VAS score at 0 hour (immediately post op), 1 hour, 2 hours, 4 hours, 8 hours, 12 hours, 18 hours and 24 hours 2. Level of Sedation by Observer Assessment of Alertness/Sedation Scale (sedation score) at 0 hour (immediately post op), 1 hour, 2 hours, 4 hours, 8 hours, 12 hours, 18 hours and 24 hours post op 3. Patient Satisfaction Score at 0 hour (immediately post op), 1 hour, 2 hours, 4 hours, 8 hours, 12 hours, 18 hours and 24 hours post op

—

Secondary

Measure	Time frame
1. Intraoperative and Postoperative Haemodynamics( SBP, DBP, MAP, PR, Spo2) 2. Postoperative nausea, vomiting and shivering 3. To measure the need for rescue analgesia 4. Total analgesic consumption in 24 hours 5. Rescue antiemetic useTimepoint: Baseline, Every 5 minutes till 40 minutes then every 10 minutes till 90 minutes.	—

Countries

India

Contacts

Public ContactDr Ranjana Khetarpal

gurpreetsingh4nov@gmail.com7986335191

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026