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A study to understand whether common painkillers affect bone healing in patients with slow-healing fractures

Outcome on study of Nonsteroidal Anti-inflammatory Drugs in delayed bone healing in a tertiary care centre - BONE-DELAY Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/109751
Enrollment
128
Registered
2026-04-29
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S698- Other specified injuries of wrist,hand and finger(s)

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: Non-steroidal Anti-inflammatory drugs.: This study investigates whether use of Nonsteroidal Anti-Inflammatory Dr

Sponsors

Dr S HARSHAVARDHAN
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18-55 years. patients admitted with distal radius fracture, shaft humerus fracture, metacarpal/metatarsal fracture, open fractures, intertrochanteric fracture, neck of femur fracture , femur shaft.

Exclusion criteria

Exclusion criteria: immunosuppressant patients e.g. HIV, chemotherapy, patients on antiplatelet, anticoagulants, immunosuppressants, diabetes, systemic hypertension, patients with renal , hepatic failure, pregnant or lactating women, obesity, protein energy malnutrition, smoking, alcohol, oncological interventions ( radiotherapy , chemotherapy )

Design outcomes

Primary

MeasureTime frame
Delayed bone healing assessed by radiological evidence of fracture union/callus formation in patients receiving NSAIDs for 5 days versus 5 days following fracture surgery.Timepoint: Postoperative Day 30 and Postoperative Day 60.

Secondary

MeasureTime frame
Incidence of malunion, nonunion, or pseudoarthrosis in study participants.Timepoint: Postoperative Day 60

Countries

India

Contacts

Public ContactHARSHAVARDHAN S

ACS Medical college

brethis.pharma@acsmch.ac.in9751666924

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026