A study comparing two types of anaesthesia (Sevoflurane-based anaesthesia and Total Intravenous Anaesthesia) in patients undergoing thyroid surgery to evaluate nerve monitoring and safety during surgery

Prospective randomized study to evaluate the effects of Sevoflurane Based Anaesthesia versus propofol based Total IntravenousAnaesthesia on Intraoperative Neuro monitoring during thyroidectomy in general anaesthesia - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/109724

Enrollment

Registered

2026-04-29

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nil: Nil Intervention2: Sevoflurane based anaesthesia: Sevoflurane based anaesthesia will be administered continuously from induction of anaesthesia until completion of surgery. The to

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient scheduled for elective thyroidectomy surgery with intraoperative neuromonitoring under general surgery . 2. Patients who provide written informed consent for participation in the study . 3.American society of anaesthesiologist (ASA) physical status I or II. 4. BMI 20 to 30 kg per metere square .

Exclusion criteria

Exclusion criteria: 1. Patients with known hypersensitivity or contraindications to sevoflurane , propofol or other anaesthetic agents used in the study. 2. Patients on medications that interfere with neuromuscular function or Anesthesia and neuromuscular disease. 3. Preexisting recurrent laryngeal or vagus nerve injury . 4. Preoperative vocal cord dysfunction on FOL (fibre optic laryngoscopy. 5.pregnant and lactating women.

Design outcomes

Primary

Measure	Time frame
1 To determine and compare the time from injection of muscle relaxant cisatracurium to initial RLN monitoring detection of the first positive EMG signal between the two groups. 2. To assess and compare the rate of positive EMG signal at initial monitoring between two groups . 3. To determine and compare the amplitude of the evoked potentials of R1, R2 between two groups.Timepoint: Outcomes will be assessed intraoperatively at predefined time points: Baseline (before induction) After induction of anaesthesia At initial intraoperative neuromonitoring (IONM) Every 5 minutes until first positive EMG signal is obtained At completion of thyroid dissection (R2 recording) At the end of surgery	—

Measure

Time frame

1 To determine and compare the time from injection of muscle relaxant cisatracurium to initial RLN monitoring detection of the first positive EMG signal between the two groups. 2. To assess and compare the rate of positive EMG signal at initial monitoring between two groups . 3. To determine and compare the amplitude of the evoked potentials of R1, R2 between two groups.Timepoint: Outcomes will be assessed intraoperatively at predefined time points: Baseline (before induction) After induction of anaesthesia At initial intraoperative neuromonitoring (IONM) Every 5 minutes until first positive EMG signal is obtained At completion of thyroid dissection (R2 recording) At the end of surgery

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Secondary

Measure	Time frame
1. Episodes of bucking & movement during surgery. 2. Heart rate , systolic blood pressure, diastolic blood pressure , mean arterial pressureTimepoint: Outcomes will be assessed intraoperatively at predefined time points: Baseline (before induction) After induction of anaesthesia At initial intraoperative neuromonitoring (IONM) Every 5 minutes until first positive EMG signal is obtained At completion of thyroid dissection (R2 recording) At the end of surgery	—

Measure

Time frame

1. Episodes of bucking & movement during surgery. 2. Heart rate , systolic blood pressure, diastolic blood pressure , mean arterial pressureTimepoint: Outcomes will be assessed intraoperatively at predefined time points: Baseline (before induction) After induction of anaesthesia At initial intraoperative neuromonitoring (IONM) Every 5 minutes until first positive EMG signal is obtained At completion of thyroid dissection (R2 recording) At the end of surgery

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Countries

India

Contacts

Public ContactDr Veer Pal Singh

Sawai man Singh Medical College Jaipur

drmamtasharma@hotmail.com9829566077

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026