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To compare and evaluate lidocaine lozenge 200 mg and 10% lidocaine spray in preventing blood pressure and heart rate rise during i-gel insertion and in reducing sore throat after surgery in patients under general anesthesia.

Efficacy and safety of lidocaine lozenge (200 mg) vs Lidocaine spray (10%) for the prevention of pressor response during insertion of supraglottic airway device (I-gel) and post operative sore throat in the patients undergoing elective surgery under general anesthesia - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/109683
Enrollment
128
Registered
2026-04-28
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Lidocaine lozenges 200 mg: Group A will receive Lidocaine lozenges 200 mg 15 minutes before the surgery Control Intervention1: Lidocaine spray 10%: Group B will receive Lidocaine spray

Sponsors

Geetanjali Medical College and Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients who will give consent to participate in the study 2. Patients of either gender, aged 18 to 60 years 3. Patients of ASA grade I or II posted for elective surgery under general anesthesia using i-gel

Exclusion criteria

Exclusion criteria: 1.Patients with known allergy to local anesthetics used in the study 2.Patients with history of sore throat or cough within 2 weeks before the surgery. 3.Patients with pre-operative hoarseness of voice. 4.Patients with any oral pathology or supraglottic pathology like tumors ORgrowth , stricture, ulceration 5.Presence of risk factors for regurgitation or aspiration like inadequate fasting, hiatus hernia 6.BMI greater than 35 kg per m2 7.Severe cardiac, renal or respiratory dysfunction 8.Pregnant or lactating mothers

Design outcomes

Primary

MeasureTime frame
Hemodynamic variables Heart rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Arterial Pressure (MAP) Ease of insertion of supraglottic airway device using 4 point verbal rating scale Incidence of Post operative Sore Throat using Harding and McVey score scale Timepoint: Hemodynamic Parameters at different time points: a.Baseline vitals in the preopertive room (TB) b.Pre-induction (TIP) c.At the end of induction (TIE) d.At the time of insertion of SGAD (I0) e.Every one minute after the insertion of SGAD (I1, I2, I3, I4, I5) f.Every 15 minutes till end of surgery post op monitoring - immediately after surgery, after 1 hour, after 12 hours and after 24 hours—

Secondary

MeasureTime frame
Incidence of any aversive symptoms like nausea, vomiting, gag reflex Incidence of any adverse effects like dysphagia, cough, hoarseness of voice Timepoint: Aversive symptoms at the time of administering of drug Adverse effects - immediately after surgery, after 1 hour, after 12 hours, after 24 hours—

Countries

India

Contacts

Public ContactAchyut Barmeda

Geetanjali Medical College and Hospital

partaniseema@yahoo.com9414162150

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026