Health Condition 1: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynx
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Balanced crystalloid solution (e.g., PlasmaLyte or equivalent): administered as intravenous fluid therapy intraoperatively and continued for the first 24 hours p
Sponsors
Dr Nigar Bari
Eligibility
Inclusion criteria
Inclusion criteria: Adults aged 18 to 65 years ASA physical status I to III Patients undergoing elective head and neck oncological surgery with expected duration of 4 hours or more
Exclusion criteria
Exclusion criteria: Pre-existing renal, hepatic, or metabolic disorders Ongoing sepsis or hemodynamic instability History of acid-base disorders Use of diuretics or bicarbonate therapy within 72 hours before surgery Intraoperative blood loss more than 1500 mL or requirement of massive transfusion Patients who are tracheostomised or not extubated postoperatively Preoperative hyponatremia (serum sodium less than 130 mEq per L) or hypernatremia (serum sodium more than 150 mEq per L) Preoperative serum osmolality more than 320 mOsm per kg History of congestive heart failure Pre-existing renal disease (serum creatinine more than 2 mg per dL)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterial blood gas parameters including pH, bicarbonate, base excess, serum lactate, and anion gap These parameters will be measured at baseline (before induction), at 2 hours during surgery, at the end of surgery, and 4 hours after extubationTimepoint: Baseline (before induction of anesthesia) At 2 hours during surgery At the end of surgery At 4 hours after extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum electrolytes: Sodium, potassium, chloride 24 hourly Renal parameters: Serum creatinine, blood urea nitrogen (BUN) Graft viability (clinical evaluation)Timepoint: Preoperative baseline At 24 hours postoperatively | — |
Countries
India
Contacts
Public ContactDr Nigar bari
Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun, uttarakhand
Outcome results
None listed