Health Condition 1: F339- Major depressive disorder, recurrent, unspecified Health Condition 2: F209- Schizophrenia, unspecified
Conditions
Interventions
Intervention1: Electroconvulsive therapy: Patients undergoing electroconvulsive therapy are randomised allocated to 3 groups as per the anesthetic induction agent to be recieved for electroconvulsive
Sponsors
All India Institute of Medical Sciences Raipur
Eligibility
Inclusion criteria
Inclusion criteria: ASA PS class I and II patients undergoing electroconvulsive therapy
Exclusion criteria
Exclusion criteria: Patient refusal Age less than 18 years or more than 65 years ASA PS class more than or equal to class III Pregnant and lactating patients Patients with history of substance abuse Patients with history of epilepsy or uncontrolled seizures on antiepileptics Patients with baseline heart rate less than 60 beats per min, baseline systolic blood pressure less than 100 mmHg and patients with Electrocardiogram (ECG) abnormalities. Patients with hyperkalemia Patients with any known allergy to the study drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Motor seizure duration noted from the moment ECT stimulus is given to the cessation of tonic clonic motor activity in the isolated arm Hemodynamic response ( BP,MAP,HR,SpO2) immediately post induction, post cessation of tonic clonic seizure at 1 minute, 3 minutes, 5 minutes and 10 minutes. Recovery from anesthesia- time from succinylcholine administration t spontaneous breathing, eye opening, obeying verbal commands would be recorded Pre procedural and post procedural cognitive function assessed by Mini Mental State Examination (MMSE) Timepoint: Motor seizure duration noted from the moment ECT stimulus is given to the cessation of tonic clonic motor activity in the isolated arm Hemodynamic response ( BP,MAP,HR,SpO2) immediately post induction, post cessation of tonic clonic seizure at 1 minute, 3 minutes, 5 minutes and 10 minutes. Recovery from anesthesia- time from succinylcholine administration t spontaneous breathing, eye opening, obeying verbal commands would be recorded Pre procedural and post procedural cognitive function assessed by Mini Mental State Examination (MMSE) | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic response ( BP,MAP,HR,SpO2) immediately post induction, post cessation of tonic clonic seizure at 1 minute, 3 minutes, 5 minutes and 10 minutes. Pre procedural and post procedural cognitive function assessed by Mini Mental State Examination (MMSE) Timepoint: Hemodynamic response ( BP,MAP,HR,SpO2) immediately post induction, post cessation of tonic clonic seizure at 1 minute, 3 minutes, 5 minutesand 10 minutes. MMSE done prior to procedure and one day post the procedure | — |
Countries
India
Contacts
Public ContactDr RASHMI DUBEY
All India Institute of Medical Sciences Raipur
Outcome results
None listed