Comparison of pain relief after surgery in adult patients using two different drugs (ketamine and fentanyl).

Comparison of postoperative ketamine with fentanyl infusion on rescue analgesia requirement in adult patients undergoing upper abdominal surgeries under general anesthesia - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/109658

Enrollment

Registered

2026-04-28

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: ketamine infusion: 50 mg of ketamine will be diluted to 50 ml with 0.9% saline to make a concentration of 1 mg/ml, infusion will be started at the rate of 0.002 ml/kg/min for 2hrs. Cont

Eligibility

Inclusion criteria

Inclusion criteria: ASA1,2 Patients undergoing upper abdominal surgeries

Exclusion criteria

Exclusion criteria: Pregnant women Patients with know case of psychosis and increased intraocular pressure Patients on medications for chronic pain Patients on medications for anxiety, depression or any psychiatric medication

Design outcomes

Primary

Measure	Time frame
Post operative pain scores of patients in both groups. Rescue analgesia doses of Tramadol required in both groups.Timepoint: at 10min, 1hr, 2hrs, 4hrs, 6hrs, 8hrs, 10hrs, 12hrs, 24hrs and 48hrs	—

Secondary

Measure	Time frame
Sedation scores in both groupsTimepoint: Baseline,at 10 min, 60 min, 2hrs, 4hrs,6hrs, 8hrs, 10hrs, 12hrs, 24hrs, 48hrs.;Difference in HR, BP, MAP, RR, SpO2 from baselineTimepoint: Baseline,at 10 min, 60 min, 2hrs, 4hrs,6hrs, 8hrs, 10hrs, 12hrs, 24hrs, 48hrs.;Time from extubation to requirement of first dose of rescue analgesiaTimepoint: Baseline,at 10 min, 60 min, 2hrs, 4hrs,6hrs, 8hrs, 10hrs, 12hrs, 24hrs, 48hrs.;Complications in PACU after drug infusionTimepoint: Baseline,at 10 min, 60 min, 2hrs, 4hrs,6hrs, 8hrs, 10hrs, 12hrs, 24hrs, 48hrs.;Comparison of change in HAM-A scores in two group pre & post operativelyTimepoint: Baseline,at 10 min, 60 min, 2hrs, 4hrs,6hrs, 8hrs, 10hrs, 12hrs, 24hrs, 48hrs.	—

Measure

Time frame

Sedation scores in both groupsTimepoint: Baseline,at 10 min, 60 min, 2hrs, 4hrs,6hrs, 8hrs, 10hrs, 12hrs, 24hrs, 48hrs.;Difference in HR, BP, MAP, RR, SpO2 from baselineTimepoint: Baseline,at 10 min, 60 min, 2hrs, 4hrs,6hrs, 8hrs, 10hrs, 12hrs, 24hrs, 48hrs.;Time from extubation to requirement of first dose of rescue analgesiaTimepoint: Baseline,at 10 min, 60 min, 2hrs, 4hrs,6hrs, 8hrs, 10hrs, 12hrs, 24hrs, 48hrs.;Complications in PACU after drug infusionTimepoint: Baseline,at 10 min, 60 min, 2hrs, 4hrs,6hrs, 8hrs, 10hrs, 12hrs, 24hrs, 48hrs.;Comparison of change in HAM-A scores in two group pre & post operativelyTimepoint: Baseline,at 10 min, 60 min, 2hrs, 4hrs,6hrs, 8hrs, 10hrs, 12hrs, 24hrs, 48hrs.

—

Countries

India

Contacts

Public ContactMohandeep Kaur

ABVIMS AND DR. RML HOSPITAL NEW DELHI

mdkaur@gmail.com9868952253

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026