Comparison of two anaesthesia techniques ( opioids free vs opioids sparing) in patients undergoing gallbladder surgery.

Effect of opioid sparing versus opioid free anaesthesia on perioperative hemodynamics in patients undergoing laparoscopic cholecystectomy:a randomised controlled study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/109526

Enrollment

Registered

2026-04-28

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis

Interventions

Intervention1: Effect of opioid sparing versus opioid free anaesthesia on Perioperative Hemodynamics in patients undergoing Laparoscopic Cholecystectomy: All patients underwent a comprehensive pre-ana

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I & II patients. Patients of age group 18 to 60 years posted for elective surgery under GA. BMI less than 30. Patients able to understand VAS score and willing to give informed and written consent. Patients with normal baseline hemodynamic parameters (HR, BP within normal limits) Patients with no prior opioid use within 48-72 hours preoperatively.

Exclusion criteria

Exclusion criteria: Patients with known history of allergy to study drugs used. Patients having history of neuropsychiatric disorder. Patients having history of severe cardiovascular disease. Patients with liver / kidney dysfunction. Patients with history of coagulation disorder. Patients with history of chronic pain. Patients with history of long-term use of analgesic drug. Patients with history of hypertension and on hypertensive medication.

Design outcomes

Primary

Measure	Time frame
Perioperative hemodynamic stability - Heart rate (HR), Systolic blood pressure (SBP), Diastolic blood pressure (DBP) and Mean arterial pressure (MBP) at defined time intervals.Timepoint: Before induction (T0) After induction (T1) Just after tracheal intubation (T2) At the time of skin incision for pneumoperitoneum (T3) 1 mint after Pneumoperitoneum (T4) 5 mint after pneumoperitoneum (T5) 20 mint after pneumoperitoneum (T6) 40 mint after pneumoperitoneum (T7) At the End of Surgery ( T8) Post Extubation (T9) 5 mint after post extubation (T10)	—

Measure

Time frame

Perioperative hemodynamic stability - Heart rate (HR), Systolic blood pressure (SBP), Diastolic blood pressure (DBP) and Mean arterial pressure (MBP) at defined time intervals.Timepoint: Before induction (T0) After induction (T1) Just after tracheal intubation (T2) At the time of skin incision for pneumoperitoneum (T3) 1 mint after Pneumoperitoneum (T4) 5 mint after pneumoperitoneum (T5) 20 mint after pneumoperitoneum (T6) 40 mint after pneumoperitoneum (T7) At the End of Surgery ( T8) Post Extubation (T9) 5 mint after post extubation (T10)

—

Secondary

Measure	Time frame
Postoperative pain (VAS Score) Incidence of PONV Adverse events ( Hypotension, Hypertension & Bradycardia) Sedation ( Ramsay scale )Timepoint: T0 - 2hr postoperatively T1 - 4hr postoperatively T2 - 6 hr postoperatively T3 - 8 hr postoperatively	—

Countries

India

Contacts

Public ContactDr Md Shahid Equbal

Rajendra Institute of Medical Sciences, Ranchi

mukeshkumarranchi9@gmail.com8709135297

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026