Health Condition 1: C50- Malignant neoplasm of breast Health Condition 2: O- Medical and Surgical
Conditions
Interventions
Intervention1: Esmolol group-Intraoperative Esmolol infusion: Patients allocated to the intervention group (Esmolol group) will receive Esmolol infusion 0.5mg/kg IV bolus over 10 minutes followed by 1
Sponsors
All India Institute Of Medical Sciences New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 18-70 years. 2. American Society of Anaesthesiologists (ASA) physical status I-III. 3. Scheduled for elective surgery for breast cancer (unilateral surgical procedure with or without axillary lymph node dissection).
Exclusion criteria
Exclusion criteria: 1. Patientâ??s refusal to participate. 2. Contraindications for the use of esmolol: Patients with history of asthma or chronic obstructive lung disease, heart block, ischemic heart disease, hepatic or renal disease. 3. Patients with chronic pain who are taking analgesics (opioids, NSAID, or paracetamol) regularly or 3 days before the surgery. 4. Patients with neurologic disorders or use of psychoactive drugs. 5. Patients with history of allergy to morphine or any other drug used for general anaesthesia. 6. Patients already on beta blocker medications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the pain intensity at rest 24hr after breast cancer surgery using Numerical pain rating scale (NRS) (Score 0-10 with 0 indicating the absence of pain and 10 maximum/unbearable pain).Timepoint: At 24 hrs after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| 24 hour postoperative total opoid consumption.Timepoint: At 24 hrs after surgery | — |
Countries
India
Contacts
Public ContactDr Shweta Bhopale
NATIONAL CANCER INSTITUTE, AIIMS NEW DELHI
Outcome results
None listed