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Association of Serum Inflammatory Biomarkers with Low Back Pain due to Lumbar Intervertebral Disc Prolapse

Evaluation of Inflammatory Biomarkers (L-1, IL-6 and TNF-alpha) and Comparison of Therapeutic Outcomes of Platelet-Rich Plasma and Epidural Steroid in Lumbar Intervertebral Disc Prolapse (IVDP). - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/04/109513
Enrollment
80
Registered
2026-04-27
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M512- Other thoracic, thoracolumbar andlumbosacral intervertebral disc displacement

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil

Sponsors

SRM Medical College and Hospital and research centre
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.MRI-confirmed lumbar IVDP patient 2.Symptomatic lower back pain with or without radiculopathy

Exclusion criteria

Exclusion criteria: 1.Previous spinal surgery 2.Spinal malignancy or infection 3.Systemic inflammatory/autoimmune diseases 4.Active infection or fever within 2 weeks 5.Recent trauma (within 3 months) 6.Pregnancy or lactation 7.Current use of immunosuppressive medications or corticosteroids 8.Known haematological disorders 9.Patients with implants

Design outcomes

Primary

MeasureTime frame
To compare serum levels of inflammatory biomarkers (IL-1, IL-6, and TNF alpha) between patients with lumbar intervertebral disc prolapse (IVDP) and controls without IVDP.Timepoint: Baseline (single time point before initiation of any treatment)—

Secondary

MeasureTime frame
To determine which inflammatory biomarker (IL-1, IL-6, or TNF alpha) shows the highest elevation in patients with lumbar IVDP.Timepoint: Baseline;To assess the association between serum levels of inflammatory biomarkers (IL-1, IL-6, TNF alpha) and severity of radiculopathy in patients with lumbar IVDP.Timepoint: Baseline—

Countries

India

Contacts

Public ContactDr Saravanan C R

SRM Medical College Hospital and Research Centre, Potheri.

saravanc1@srmist.edu.in9884001153

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026