Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Use of dexmedetomidine for extubation response attenuation: injection dexmedetomidine 0.5mcg/kg infusion in 100ml NS over 10 minutes around 15 minutes before planned tracheal extubation
Sponsors
PACIFIC MEDICAL COLLEGE AND HOSPITAL UDAIPUR
Eligibility
Inclusion criteria
Inclusion criteria: Patients belonging to ASA(American Society of Anesthesiologists) Grade-I and Grade-II Patient willing to give written informed consent patients undergoing elective surgery under general anesthesia with endotracheal intubation and planned for post operative extubation
Exclusion criteria
Exclusion criteria: Patients posted for emergency surgeries patients with Known hypersensitivity or allergy to any drug used in study Patient refusal to written informed consent Patients belonging to ASA grade-III or above patients having Difficult airway (Mallampati score III and IV) Patients requiring postoperative mechanical ventilation Patients with Baseline bradycardia (heart rate patients with Hypotension (systolic blood pressure Pregnant or lactating women Obesity (body mass index > 30 kg/m ) Patients with significant respiratory disease or with recent upper respiratory tract infection Patients with significant hepatic or renal dysfunction Patients with significant cardiovascular disease Patients receiving medications affecting heart rate or blood pressure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| evaluating the effect of dexmedetomidine 0.5mcg/kg to attenuate the hemodynamic parameters and recovery characteristics during tracheal extubation Timepoint: evaluating the effect of dexmedetomidine 0.5mcg/kg to attenuate the hemodynamic parameters and recovery characteristics 1 minute before drug administration , during drug administration at 3,7,10 minutes , 1 minute pre-extubation ,at the time of extubation and post-extubation at 2,6,8,10 minutes | — |
Secondary
| Measure | Time frame |
|---|---|
| To document side effects During & post drug administration if anyTimepoint: at drug administration & at 3 minutes 7 minutes 10 minutes post extubation;Emergence time from stopping anesthetic to eye opening & Extubation quality scoring during extubationTimepoint: after stopping anesthetic drug, 1 minute before extubation & at time of extubation 0 minute & post extubation at 1 minute 3 minute;to document modified ramsay sedation scoreTimepoint: at the time of extubation 0minute & post extubation 1 minute 5 minutes 10 minutes 15 minutes & 30 minutes;to document timeline for recovery that is modified aldrete scoreTimepoint: 5 minutes 10 minutes 15 minutes after extubation then every 15 minutes until aldrete score is equal to or more than 9 | — |
Countries
India
Contacts
Public ContactDr Ravindra Singh Chouhan
Pacific Medical College and Hospital, udaipur
Outcome results
None listed