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A Clinical Study on Pain Relief After Root Canal: Are Gabapentin and Pregabalin Better Than Ibuprofen?

Comparative Evaluation Of Gabapentin And Pregabalin Versus Ibuprofen As Pre-medication Drugs In Reduction Of Post-endodontic Pain : A Randomised Controlled Clinical Trial With Questionnaire Based Assessment Of Clinician Awareness - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/109427
Enrollment
45
Registered
2026-04-27
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Comparative Evaluation Of Gabapentin As Pre-medication Drug: single dose of 300mg 30 minutes before treatment Control Intervention1: Pregabalin as pre-medication drug.: 75mg single dose

Sponsors

Government Dental College and hospital Ahmedabad
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Symptomatic irreversible pulpitis with greater than 4 on numerical rating scale

Exclusion criteria

Exclusion criteria: History of allergy of study drugs. Pregnant or lactating women. Patients on analgesics or anticonvulsants. Medically compromised patients.

Design outcomes

Primary

MeasureTime frame
Gabapentin and pregabalin expected to reduce postoperative pain significantly Pregabalin anticipated to show superior analgesic efficacy Timepoint: 4 h, 8 h, 12 h, 24 h, 48 h, and 72 h intervals—

Secondary

MeasureTime frame
Reduced need for rescue analgesics. Timepoint: 4 h, 8 h, 12 h, 24 h, 48 h, & 72 h intervals—

Countries

India

Contacts

Public ContactDr Shikha Kanodia

Government Dental College and Hospital Ahmedabad

shikhakk@yahoo.co.in9825465861

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026