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Study to assess the effect of injection around the vagus nerve with 5% dextrose over neck with general anaesthesia on post-operative recovery quality compared to the general anesthesia with epidural analgesia over back of the patient

Effect of ultrasound guided bilateral vagus nerve hydrodissection on quality of recovery in patirnt undergoing major abdominal surgery under general anaesthsia with thoracic epidural analgesia vs general anaesthsia with thoracic epidural analgesia only:an exploratory double blinded randomised controlled trial. - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/109421
Enrollment
76
Registered
2026-04-27
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Ultrasound guided bilateral vagus nerve hydrodissection: In the intervention group, ultrasound-guided bilateral vagus nerve hydrodissection will be performed at the cervical level (C6 C

Sponsors

Dr Nitesh Kumar Jha
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA Grade I- III Patient undergoing major open abdominal surgry under general anaesthesia along with thoracic epidural analgesia

Exclusion criteria

Exclusion criteria: Patient refusal Severe systemic medical illness (NYHA class III-IV heart failure, previous MI, atrial fibrillation, cerebrovascular disease, chronic kidney disease under hemodialysis) Anaesthesia conditions where thoracic epidural anaesthesia cannot be given along with GA Patients medical conditions- where outcome parameters could not be assessed like language and intellectual disability

Design outcomes

Primary

MeasureTime frame
Quality of recovery -15Timepoint: 24 hour,3 days and 7 days after surgery—

Secondary

MeasureTime frame
Pain score (NRS)Timepoint: 1,2,6,12,24,48,72 hour and 7 days after surgery;Pittsburg sleep quality indexTimepoint: 24 hour and 7 days after surgery;Patient health questionnaire-9Timepoint: 24 hour anf 7 days after surgery;Clavien-Dindo classification fot postoperative surgical complicationsTimepoint: ;Total analgesic dose requirement after surgeryTimepoint:—

Countries

India

Contacts

Public ContactNitesh Kumar Jha

All India Institute of medical Science,Rishikesh

niteshkashyp16@gmail.com8073722850

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026