Comparing Three Remineralizing Gels for Treating White Spot Marks After Braces in Children Using a Custom Essix Tray.

Comparative Evaluation of Casein Phosphopeptide-Amorphous Calcium Phosphate Gel, Calcium Sucrose Phosphate Gel and a Novel Herbal-Nano Hydroxyapatite Gel in the Management of Post Orthodontic White Spot Lesions in Children by Using a Modified Essix Appliance a Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/109395

Enrollment

Registered

2026-04-27

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Casein Phosphopeptide Amorphous Calcium Phosphate Tooth Mousse (Modified Essix Appliance with Reservoirs): Casein phosphopeptide amorphous calcium phosphate is a well-established remine

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients with post orthodontic white spot lesions who had started orthodontic or myofunctional appliance therapy at or below 13 years of age. 2 Presence of more than or equal to 2 noncavitated WSLs (White Spot Lesions) on maxillary anterior teeth, visible with or without air drying after debonding (ICDAS II score 1 or 2). 3 Good general health. 4 Parent/Guardian willing to give written informed consent.

Exclusion criteria

Exclusion criteria: 1 Allergy to one of the components of the product. 2 Cavitated lesions (ICDAS more than or equal to 3). 3 Fluorosis, MIH, or enamel hypoplasia. 4 Dentin caries or restorations on index teeth. 5 Patients who have received professional fluoride therapy within the previous three months will be excluded from the study.

Design outcomes

Primary

Measure	Time frame
Primary outcome Reduction in white spot lesion area measured using ImageJ analysis at baseline 4 weeks 8 weeks and 12 weeksTimepoint: 2 years 2 months	—

Secondary

Measure	Time frame
Change in ICDAS II scores over time Inter group comparison of remineralizing agents Intra group comparison of lesion improvement at different time intervalsTimepoint: 2 years, 2 months	—

Countries

India

Contacts

Public ContactAnkita Shintre

MIDSR, Dental College, Latur

ankitashintre131@gmail.com9146599839

Outcome results