A study to compare two fluids that are given intravenously during a surgery for brain tumor.

Comparison of Normal saline and Balanced crystalloid Plasmalyte in patients undergoing elective craniotomy for intracranial brain tumors- Randomised controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/109370

Enrollment

Registered

2026-04-27

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C719- Malignant neoplasm of brain, unspecified Health Condition 2: C719- Malignant neoplasm of brain, unspecified Health Condition 3: O- Medical and Surgical

Interventions

Intervention1: Balanced crystalloid Plasmalyte: Balanced crystalloid PlasmaLyte will be administered intravenously intraoperatively. The fluid deficit and maintenance fluid will be calculated initiall

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 and 2 Posted for elective craniotomy for intracranial brain tumor resection. Able to provide informed and written consent.

Exclusion criteria

Exclusion criteria: Pre existing acid base and electrolyte disturbances Pre existing renal failure Hypersensitivity to study solutions Surgery involving blood loss more than 1.5 litres Surgeries of more than 6 hours duration

Design outcomes

Primary

Measure	Time frame
To evaluate acid base status To evaluate serum electrolyte status To evaluate renal function testTimepoint: T1 Baseline after induction T2 At the time of dura opening T3 One hour after dura opening T4 At skin closure T5 One hour post operatively T6 24 hours post operatively T7 48 hours post operatively	—

Secondary

Measure	Time frame
To assess plasma osmolality To assess intra operative brain relaxation scoreTimepoint: From baseline after induction to 48 hours post operatively. Brain relaxation score will be observed intraoperatively .	—

Countries

India

Contacts

Public ContactAnjna Dang

saurabh31.7.dmch@gmail.com07079893536

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026