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A Study on How Different Doses of a Pre-Surgery Sedative Affect the Amount of Anaesthesia Required to Induce Sleep

Effect of Two Different Doses of Dexmedetomidine Premedication on Propofol Requirement for Induction of Anaesthesia A Double blinded Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/109360
Enrollment
72
Registered
2026-04-27
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine 0.5mcg per kg: patients will receive injection dexmedetomidine 0.5mcg per kg in 100ml NS,intravenously over 10minutes, 10 minutes prior to induction of anaesthesia Inter

Sponsors

Chettinad Hospital and Research Institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients belong to ASA I or II Scheduled for elective surgeries under General Anaesthesia

Exclusion criteria

Exclusion criteria: Patients with Known Allergy or hypersensitivity to Dexmedetomidine or Propofol Patients with baseline HR less than 50bpm,Hypotension Patients with Heartblocks,arrythmia Pregnant women BMI more than 35kg per square meter

Design outcomes

Primary

MeasureTime frame
Total dose of propofol required for induction of anaesthesia in mg per kgTimepoint: Measured from start of propofol administration until loss of verbal response

Secondary

MeasureTime frame
Preoperative anxiety score assessed using Amstredam Preoperative Anxiety and Information ScaleTimepoint: Before Administration of Study Drug and after 10min of administration of Study Drug;Sedation score assessed using Ramsay Sedation ScoreTimepoint: 10min After administration of Study Drug Pre induction After induction at 1min,3min,5min,10min

Countries

India

Contacts

Public ContactDr Anand S

Chettinad Hospital and Research Institute

dranandmurugan@gmail.com9444486183

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026