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To study two methods of setting ventilator pressure at the end of the breath to improve lung inflation (determined using bedside ultrasound) in patients with acute respiratory distress syndrome (ARDS), in supine and prone body position.

Effect of Positive End-Expiratory Pressure (PEEP) application guided by Transpulmonary pressure (Ptp) vs ARDS Network-recommendation on Lung Aeration during supine and prone positioning in patients with moderate to severe acute respiratory distress syndrome (ARDS): A prospective randomised controlled study. - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/109348
Enrollment
60
Registered
2026-04-24
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J22- Unspecified acute lower respiratory infection

Interventions

Intervention1: Positive end expiratory pressure (PEEP) guided by Transpulmonary pressure: Lung aeration using lung ultrasound score in supine and prone position when positive end expiratory pressure i

Sponsors

AIIMS JODHPUR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient with moderate to severe ARDS (P/F ratio less than 150) in whom the invasive mechanical ventilation (IMV) has been initiated within 36- 48 h and are planned for proning session.

Exclusion criteria

Exclusion criteria: Pregnancy, cardiac disease Chest wall deformity, head injury, end-stage organ failure, Hemodynamic instability requiring dual vasopressors, contraindication to esophageal catheter placement (facial fracture, GI Bleed), severe respiratory central depression and neuromuscular conduction block diseases

Design outcomes

Primary

MeasureTime frame
Comparison of the change in the lung aeration scores from supine to prone positioning between the two PEEP application strategies (ARDSNet and TPP guided)Timepoint: T1- Before randomisation in supine position T2- After randomisation and intervention according to group in supine position T3 30 minutes after prone position—

Secondary

MeasureTime frame
Comparison of respiratory mechanics (static lung compliance, peak airway pressure, plateau airway pressure, and mean airway pressure) in supine and prone positions between the two groupsTimepoint: Before and after randomization in supine position and 30 min after proning.;Comparison of PaO2, P/F ratio, A-a gradient and dead space (Vd/Vt) in supine and prone positions between the two groupsTimepoint: Before and after randomization in supine position and 30 min after proning.;Ventilatory free days/length of stay in ICU/mortality in ICU between the two groups.Timepoint: During the ICU stay—

Countries

India

Contacts

Public ContactRakshita Prajapat

All india institute of medical sciences, Jodhpur

drmsadik@gmail.com9414849733

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026