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Comparison of High-Flow Nasal Oxygen and Non-Invasive Ventilation in Patients with Acute COPD Exacerbations and Type II Respiratory Failure

COMPARATIVE EVALUATION OF EFFECTS OF HIGH FLOW NASAL OXYGEN THERAPY AND NON- INVASIVE VENTILATION IN PATIENTS WITH ACUTE EXACERBATION OF COPD IN COMBINATION WITH TYPE TWO RESPIRATORY FAILURE - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/109341
Enrollment
100
Registered
2026-04-24
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J00-J99- Diseases of the respiratory system

Interventions

Intervention1: HIGH FLOW NASAL OXYGENAION: High-flow nasal oxygenation (HFNO) or high-flow nasal cannula (HFNC) is a noninvasive respiratory support system that delivers heated, fully humidified, and

Sponsors

Hindu Rao Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Diagnosed mild to moderate AECOPD with Type 2 respiratory failure Patient or legally authorized representative providing informed consent

Exclusion criteria

Exclusion criteria: ANY NEED FOR URGENT INTUBATION PH LESS THAN 7.2 Severe hypoxia pO2 LESS THAN 50 Respiratory rate LESS THAN 8 or MORE THAN 40 Inability to protect airways Respiratory or cardiac arrest Requirement for urgent intubation Factors such as suspected drug overdose, end-stage cancer, cerebrovascular accident, recent myocardial infarction, hemodynamic instability, HISTORY OF Pulmonary Kochs Ischemic Heart Disease Arrythmias Pericarditis Pulmonary edema Pleural effusion

Design outcomes

Primary

MeasureTime frame
To compare the decrease in PaCO2 levels in the patients of AECOPD with T2RF with HFNO in comparison to NIV.Timepoint: AT ICU admission (T1) o 2 HRS after intervention (T2) o 6 HRS after intervention (T3) o 12 HRS after intervention (T4) o 18 HRS after intervention (T5) o 24 HRS after intervention (T6)

Secondary

MeasureTime frame
To compare change in pao2 levels with HFNO & NIV To compare patient comfort with HFNO & NIV To compare treatment failure rates between the two groupsTimepoint: AT ICU admission (T1) o 2 HRS after intervention (T2) o 6 HRS after intervention (T3) o 12 HRS after intervention (T4) o 18 HRS after intervention (T5) o 24 HRS after intervention (T6)

Countries

India

Contacts

Public ContactDR SANJAY KUMAR GUPTA

Hindu Rao Hospital Delhi

hodanesthesiahrh@gmail.com9810655949

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026